目的 探讨宁泌泰胶囊联合头孢曲松钠治疗急性肾盂肾炎的临床疗效。方法 选取2012年12月-2015年9月都江堰市中医医院收治的急性肾盂肾炎的患者234例,随机分为对照组(114例)和治疗组(120例)。对照组患者静脉滴注注射用头孢曲松钠,2 g加入到0.9%氯化钠溶液250 mL中,1次/d。治疗组在对照组基础上口服宁泌泰胶囊,4粒/次,3次/d。两组患者均持续治疗2周。观察两组临床疗效,同时比较两组尿路刺激征及发热等临床症状消失时间。结果 治疗后,对照组和治疗组总有效率分别为88.6%、91.7%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者尿路刺激征、腰酸痛及发热的消失时间明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者尿红细胞和白细胞计数均显著下降,同组治疗前后差异具有统计学意义(P<0.05);且治疗后,治疗组这些观察指标改善程度显著优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 宁泌泰胶囊联合头孢曲松钠治疗急性肾盂肾炎疗效显著,能够明显改善患者的尿痛、尿频等尿路刺激征及腰酸痛等临床症状,具有一定的临床推广应用价值。

ObjectiveTo explore the clinical effect of Ningmitai Capsules combined ceftriaxone sodium in treatment of acute pyelonephritis.Methods Patients (234 cases) with acute pyelonephritis in Dujiangyan Traditional Chinese Medicine Hospital from December 2012 to September 2015 were randomly divided into control (n=114) and treatment (n=120) groups. Patients in the control group were iv administered with Ceftriaxone Sodium for injection, 2 g added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Ningmitai Capsules on the basis of control group, 4 grains/time, three times daily. The patients in two groups were treated for 2 weeks. After treatment, the efficacies were evaluated, and the disappeared times of clinical symptoms such as urinary irritation symptoms and fever was compared.Results After treatment, the efficacies in the control and treatment groups were 88.6% and 91.7%, respectively, and there was difference between groups (P < 0.05). After treatment, the disappeared times of urinary irritation symptoms, backache, and fever in the treatment group were shorter than those in the control group, and there were differences in two groups (P < 0.05). After treatment, urine red blood cell and white blood cell count in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05).Conclusion Ningmitai Capsules combined ceftriaxone sodium has clinical curative effect in treatment of acute pyelonephritis, can significantly improve clinical symptoms such as urinary frequency, urine pain, which has a certain clinical application value.