目的 探讨牛痘疫苗致炎兔皮提取物注射液联合甲钴胺治疗化疗所致周围神经病变的临床疗效。方法 选取常熟市第一人民医院2013年2月-2015年3月收治的周围神经病变患者146例,随机分为对照组和治疗组,每组各73例。对照组im甲钴胺注射液0.5 mg/次,1次/d;治疗组在对照组的基础上静脉滴注牛痘疫苗致炎兔皮提取物注射液,7.2 U溶于250 mL生理盐水中,1次/d。两组患者均持续治疗2周。观察两组患者临床疗效,比较治疗前和治疗1周、2周后两组的神经传导速度和VAS评分的变化。结果 治疗后,对照组和治疗组总有效率分别为58.90%、89.04%,两组比较差异有统计学意义(P<0.05)。治疗1周后,两组患者感觉神经和运动神经传导速度均得到改善,两组比较差异具有统计学意义(P<0.05)。治疗2周后,两组患者感觉神经和运动神经传导速度均较治疗前显著改善,治疗组和同组治疗1周后、对照组比较差异具有统计学意义(P<0.05)。治疗1周后,两组患者的VAS评分均低于治疗前,两组比较差异具有统计学意义(P<0.05)。治疗2周后,两组患者的VAS评分均较治疗前显著降低,治疗组和同组治疗1周后、对照组相比差异具有统计学意义(P<0.05)。结论 牛痘疫苗致炎兔皮提取物注射液联合甲钴胺治疗化疗所致周围神经病变的临床疗效较好,可显著改善患者的神经传导速度,提高生活质量,安全性较高,具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of extracts injection from rabbit skin inflamed by vaccinia virus combined with mecobalamine in treatment of chemotherapy-induced peripheral neuropathy.Methods Patients (146 cases) with peripheral neuropathy in Changshu No.1 People's Hospital from February 2013 to March 2015 were divided into control and treatment groups, and each group had 73 cases. The patients in the control group were im administered with Mecobalamin Injection, 0.5 mg/time, once daily. The patients in the treatment group were iv administered with rabbit skin inflamed by vaccinia virus, 7.2 U added into 250 mL normal saline, once daily. The patients in two groups were treated for two weeks. The clinical efficacies in two groups were observed, and the changes of nerve conduction velocity and VAS scores were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 58.90% and 89.04%, respectively, and there was difference between groups (P<0.05). After one week of treatment, sensory nerve conduction velocity and motor nerve conduction velocity in two groups were both improved, and there were differences between two groups (P < 0.05). After two weeks of treatment, sensory nerve conduction velocity and motor nerve conduction velocity were better than those before treatment, and there were differences between two groups (P < 0.05). After one week of treatment, VAS scores in two groups were lower than those before treatment, and there were differences between two groups (P < 0.05). After two weeks of treatment, VAS scores in two groups were lower than those before treatment, and there were differences between two groups (P < 0.05).Conclusion Extracts injection from rabbit skin inflamed by vaccinia virus combined with mecobalamine has clinical curative effect in treatment of chemotherapy-induced peripheral neuropathy, and can significantly improve nerve conduction velocity and improve the quality of life with high safety, which has a certain clinical application value.