目的 研究阿托伐他汀钙片联合阿魏酸哌嗪片治疗糖尿病肾病的临床效果。方法 将汉中市中心医院2012年11月-2015年1月收治的糖尿病肾病患者80例,随机分为对照组和治疗组,每组各40例。对照组在基础治疗的基础上给予阿魏酸哌嗪片,2片/次,2次/d;治疗组在对照组的基础上口服阿托伐他汀钙片20 mg/d,1次/d,两组均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后肾功能指标24 h尿蛋白定量、肌酐和尿素,三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、总胆固醇(TC)的变化。结果 治疗后,对照组和治疗组的总有效率分别为70.0%、90.0%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的肾功能指标24 h尿蛋白定量、尿素、肌酐均较治疗前有所改善,且差异有统计学意义(P<0.05);且治疗组治疗后肾功能指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05);两组患者的血脂水平TG、LDL、TC均较治疗前显著降低,HDL显著升高,且差异有统计学差异(P<0.05);且治疗组治疗后血脂水平的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 阿托伐他汀钙片联合阿魏酸哌嗪片治疗糖尿病肾病具有较好的临床效果,能改善肾功能和血脂,且安全性较高,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Atorvastatin Calcium Tablets combined with Piperazine Ferulate Tablets in treatment of diabetic nephropathy.MethodsPatients (80 cases) with diabetic nephropathy in Hanzhong Central Hospital from November 2012 to January 2015 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were po administered with Piperazine Ferulate Tablets on the basis of basic treatment, 2 tablets/time, twice daily. The patients in the treatment group were po administered with Atorvastatin Calcium Tablets on the basis of the control group, 20 mg/d, once daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of renal function indexes 24 h urine protein, creatinine, and urea, triacylglycerol (TG), low density lipoproteins (LDL), high density lipoprotein (HDL), and total cholesterol (TC) in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 70.0% and 90.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, renal function indexes 24 h urine protein, creatinine, and urea in two groups were significantly improved, and the difference was statistically significant in the same group (P < 0.05). And those renal function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, lipid levels TG, LDL, and TC in two groups were significantly decreased, and HDL were increased with significant difference (P < 0.05). And those lipid levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Atorvastatin Calcium Tablets combined with Piperazine Ferulate Tablets has clinical curative effect in treatment of diabetic nephropathy, and can improve the renal function indexes and lipid levels with high safety, which has a certain clinical application value.