目的 探讨复方丹参滴丸联合苯磺酸左旋氨氯地平片治疗老年单纯收缩期高血压患者的临床疗效。方法 选取北京市密云区果园社区卫生服务中心2014年8月-2015年8月就诊的单纯收缩期高血压患者80例,所有患者按照随机数表法随机分为对照组和治疗组,每组各40例。两组患者给予常规降压治疗。对照组口服苯磺酸左旋氨氯地平片,5 mg/次,1次/d;治疗组在对照组基础上口服复方丹参滴丸,40丸/次,2次/d。两组患者均持续治疗3个月。观察两组的临床疗效,比较治疗前后两组患者各项血压指标、血脂指标、血压节律昼夜变化有效率、肱动脉血管内径及扩张情况。结果 治疗后,对照组、治疗组总有效率分别为72.50%、92.50%,两组患者总有效率比较差异具有统计学意义(P<0.05)。治疗后,两组患者的24 h舒张压、24 h收缩压、白昼血压负荷以及夜间血压负荷均显著降低,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者TC、LDL-C均显著降低,同组治疗前后差异均具有统计学意义(P<0.05);且治疗组这些观察指标降低程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组舒张压和收缩压的血压节律昼夜变化有效率分别为30.00%、35.00%,治疗组的分别为80.00%、87.50%,两组患者舒张压和收缩压的血压节律昼夜变化有效率比较差异具有统计学意义(P<0.05)。治疗后,两组患者血管扩张百分比显著升高,同组治疗前后差异均具有统计学意义(P<0.05);且治疗组这个观察指标升高程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 复方丹参滴丸联合苯磺酸左旋氨氯地平片治疗老年单纯收缩期高血压具有较好临床症状,能够提高血压节律昼夜变化有效率,无明显不良反应,具有一定的临床推广应用价值。

Objective To discuss the clinical effect of Compound Danshen Dripping Pills combined with Levamlodiping Besylate Tablets in treatment of elderly isolated systolic hypertension.Methods Patients (80 cases) with isolated systolic hypertension in Beijing Miyun District Guoyuan Community Health Service Center from August 2014 to August 2015 were divided into control and treatment groups according to the random number table, and each group had 40 cases. All patients in two groups were given the conventional treatment. The patients in the control group were po administered with Levamlodiping Besylate Tablets, 5 mg/time, once daily. The patients in the treatment group were poadministered with Compound Danshen Dripping Pills on the basis of control group, 40 pills/time, twice daily. The patients in two groups were treated for 3 months. After treatment, the efficacies were evaluated, and the blood pressure indicators, blood lipid changes, the circadian rhythm of blood pressure changes, inner diameter of blood and expansion in two groups were compared.Results After treatment, the efficacies in the control and treatment groups were 72.50% and 92.50%, respectively, and there were differences between two groups (P<0.05). After treatment, 24 h diastolic blood pressure, 24 h systolic blood pressure, daytime blood pressure load, and the value of nighttime blood pressure load in two groups were significantly decreased, with significant difference between two groups (P < 0.05). After treatment, the levels of TC and LDL-C in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly decreased than those in the control group, with significant difference between two groups (P < 0.05). Circadian rhythms of diastolic and systolic blood pressure changes in the control and treatment groups were 30.00%, 35.00% and 80.00%, 87.50%, respectively, and there were differences between two groups (P<0.05). After treatment, blood expansions in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, blood expansions in two groups were significantly decreased, with significant difference between two groups (P < 0.05).Conclusion Compound Danshen Dripping Pills combined with Levamlodiping Besylate Tablets has clinical curative effect in the treatment of elderly isolated systolic hypertension, can raise blood pressure circadian rhythm changes efficiently, is less adverse reactions, which has a certain clinical application value.