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[摘要]
目的 研究小剂量人血白蛋白联合参芎葡萄糖注射液治疗急性进展性脑梗死的疗效。方法 选取天津市天津医院2013年8月-2015年6月住院的急性进展性脑梗死患者90例,随机分为对照组和治疗组,每组各45例。两组均给予药物基础治疗。对照组静脉滴注参芎葡萄糖注射液100 mL/次,1次/d;治疗组在对照组治疗基础上静脉滴注20%人血白蛋白50 mL,1次/d。两组患者均连续治疗14 d。观察两组的临床疗效,比较两组治疗前后NHISS评分、Barthel指数和血液流变学。结果 治疗后,对照组和治疗组总有效率分别为57.78%、84.44%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分较治疗前明显下降,Barthel指数较治疗前明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者全血黏度、血浆黏度、红细胞比容、纤维蛋白原均较治疗前明显下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 小剂量人血白蛋白联合参芎葡萄糖注射液治疗急性进展性脑梗死具有较好的临床效果,能够显著降低NIHSS评分,明显升高Barthel指数,并能明显改善患者的血液流变学指标,具有一定的临床推广应用价值。
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[Abstract]
Objective To observe the clinical effect of low-dose Human Albumins combined with Salivae Miltiorrhizae, Liguspyragine Hydrochloride and Glucose Injection (SGI) in treatment of acute progressing cerebral infarction.Methods Patients (90 cases) with acute progressing cerebral infarction in Tianjin Hospital from August 2013 to June 2015 were randomly divided into control and treatment groups, and each group had 45 cases. All patient in two groups were treated with the basic therapy. Patients in the control group were iv administered with SGI, 100 mL/time, once daily. Patients in the treatment group were iv administered with 20% Human Albumins on the basis of the control group, 50 mL/time, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and NIHSS score, Barthel index, and hemorheological indexes before and after treatment in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 57.78% and 84.44%, respectively, and there were differences between two groups (P < 0.05). After treatment, NIHSS scores in two groups were significantly decreased, but Barthel indexes were significantly increased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen were significantly decreased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Low-dose Human Albumins combined with SGI has clinical curative effect in treatment of acute progressing cerebral infarction, and can significantly reduce NIHSS scores, increase Barthel indexes, obviously improve hemorheological indexes, which has a certain clinical application value.
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