目的 观察骨松宝胶囊联合胰岛素注射液治疗2型糖尿病性骨质疏松症的临床疗效。方法 选取西安市第五医院2013年7月-2014年7月收治的2型糖尿病性骨质疏松患者98例,随机分为治疗组和对照组,每组各49例。对照组餐前皮下注射胰岛素注射液,起始剂量为4~6 U/次,3次/d。根据患者血糖监测结果,适当调整剂量。治疗组在对照组的基础上口服骨松宝胶囊,2粒/次,3次/d。两组患者均连续治疗1年。观察两组的临床疗效,同时比较两组患者治疗前后骨密度(BMD)、血钙、骨钙素(BGP)、血磷、骨特异性碱性磷酸酶(B-ALP)以及骨痛症状评分的变化。结果 治疗后,对照组和治疗组的总有效率分别为79.6%、93.9%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者腰椎、股骨颈、股骨大转子的BMD显著升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些指标改善幅度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者B-ALP均显著降低,BGP均显著升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者骨痛症状评分显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组骨痛症状评分下降明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 骨松宝胶囊联合胰岛素注射液治疗2型糖尿病性骨质疏松症疗效较好,能显著改善患者骨痛症状,具有一定的临床推广应用价值。

Objective To observe the clinical effect of Gusongbao Capsules combined with Insulin Injection in treatment of type 2 diabetic osteoporosis. Methods Patients (98 cases) with type 2 diabetic osteoporosis in the Fifth Hospital of Xi'an City from July 2013 to July 2014 were divided into control and treatment groups, and each group had 49 cases. Patients in the control group were sc administered with Insulin Injection, with the starting dosage of 4-6 U/time, three times daily, and the dose was adjusted according to the results of blood glucose monitoring. Patients in the treatment group were po administered with Gusongbao Capsules on the basis of the control group, 2 grains/time, three times daily. The patients in two groups were treated for 1 year. After treatment, the clinical efficacy was evaluated, and the changes of bone mineral density (BMD), serum calcium, serum osteocalcin (BGP), phosphorus, bone specific alkaline phosphatase (B-ALP) and bone pain symptom score before and after treatment in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.6% and 93.9%, respectively, and there were differences between two groups (P > 0.05). After treatment, the BMD of lumbar spine, femoral neck, and greater trochanter of femur in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, B-ALP in two groups were significantly decreased, and BGP in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, bone pain symptom score in two groups were significantly decreased, and difference was statistically significant in the same group (P < 0.05). And bone pain symptom score in the treatment group was significantly better than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Gusongbao Capsules combined with Insulin Injection has clinical curative effect in treatment of type 2 diabetic osteoporosis, can significantly improve the bone pain symptom of patients, which has a certain clinical application value.