目的 研究糖脉康颗粒联合甲钴胺注射液和α-硫辛酸注射液治疗糖尿病周围神经病变的临床疗效。方法 选取2014年6月-2015年6月成都新华医院收治的糖尿病周围神经病变患者170例,按照随机数字表法将患者分为治疗组和对照组,每组各85例。所有患者均给予饮食、运动治疗、口服降糖药或者胰岛素基础治疗。在此基础治疗上,对照组肌肉注射甲钴胺注射液,0.5 mg/次,2天1次;静脉滴注α-硫辛酸注射液,600 mg加入到250 mL生理盐水中,1次/d。治疗组在对照组的基础上给予糖脉康颗粒,1袋/次,3次/d。两组患者均持续治疗1个月。观察两组患者临床疗效,比较治疗前后总胆固醇(TC)、糖化血红蛋白(HbA1c)、血尿素氮(BUN)及神经传导速度的变化。结果 治疗后,对照组和治疗组总有效率分别为70.6%、90.6%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者TC、HbA1c及BUN均显著降低,同组治疗前后差异均具有统计学意义(P<0.05);且治疗组这些观察指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者神经传导速度显著增加,同组治疗前后差异均具有统计学意义(P<0.05);且治疗组神经传导速度增加明显高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 糖脉康颗粒联合甲钴胺注射液和α-硫辛酸注射液治疗糖尿病周围神经病变的临床疗效较好,可改善糖代谢和脂代谢情况,增加神经传导速度,具有一定的临床推广应用价值。

Objective To study the clinical effect of Tangmaikang Granules combined with Mecobalamin Injection and α-Lipoic Acid Injection in treatment of diabetic peripheral neuropathy. Methods Patients (170 cases) with diabetic peripheral neuropathy in Chendu Xinhua Hospital from June 2014 to June 2015 were divided into control and treatment groups according to the random number table, and each group had 85 cases. All patients were given conventional basic treatment with diet, exercise, oral hypoglycemic drugs, and insulin. The patients in the control group was im administered with Mecobalamin Injectionm, 0.5 mg/time, once every other day. They were also iv administered with α-Lipoic Acid Injection, 600 mg added into 250 mL of normal saline, once daily. The patients in the treatment group were given Tangmaikang Granules, 1 bag/time, three times daily. The patients in two groups were treated for 1 month. The clinical efficacies in two groups were observed, and the changes of total cholesterol (TC), glycosylated hemoglobin (HbA1c), blood urea nitrogen (BUN), and nerve conduction velocity were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 70.6% and 90.6%, respectively, and there was difference between groups (P < 0.05). After treatment, TC, HbA1c, and BUN in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, nerve conduction velocity in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And nerve conduction velocity in the treatment group was significantly better than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Tangmaikang Granules combined with Mecobalamin Injection and α-Lipoic Acid Injection has clinical curative effect in treatment of diabetic peripheral neuropathy, and can improve glucose metabolism and lipid metabolism, and increase nerve conduction velocity, which has a certain clinical application value.