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[摘要]
目的 观察宫瘤消胶囊联合甲睾酮和米非司酮治疗绝经期子宫肌瘤的临床疗效。方法 选取2012年3月-2014年7月衡水市第二人民医院妇科进行治疗绝经期子宫肌瘤患者112例,随机分为对照组和治疗组,每组各56例。对照组患者口服甲睾酮片,1片/次,1次/d;并在睡觉前口服米非司酮片,1片/次,1次/d。治疗组在对照组治疗基础上口服宫瘤消胶囊,4粒/次,3次/d。两组均连续治疗6个月。观察两组的临床疗效,同时比较两组治疗前后子宫体积、肌瘤体积、促卵泡激素(FSH)、孕酮(P)、雌二醇(E2)、黄体生成素(LH)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为80.36%、91.07%,两组比较差异有统计学意义(P<0.05)。治疗后,两组子宫体积、肌瘤体积均明显缩小,两组E2、P、FSH水平均较治疗前显著下降,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论 宫瘤消胶囊联合甲睾酮和米非司酮治疗绝经期子宫肌瘤效果较好,可显著缩小肌瘤体积,降低E2、P、FSH水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To observe the clinical effect of Gongliuxiao Capsules combined with methyltestosterone and mifepristone in treatment of menopause uterine fibroids. Methods Patients (112 cases) with menopause uterine fibroids in Department of Gynaecology of the Second People's Hospital of Hengshui from March 2012 to July 2014 were randomly divided into control (n=56) and treatment (n=56) groups. The patients in the control group were po administered with Methyltestosterone Tablets, 1 tablet/time, once daily. And they were po administered with Mifepristone Tablets before sleep, 1 tablet/time, once daily. The patients in the treatment group were po administered with Gongliuxiao Capsules on the basis of the control group, 4 grains/time, three times daily. The patients in two groups were treated for 6 months. After treatment, the efficacy was evaluated, and the changes of uterine volume, fibroid volume, FSH, P, E2, and LH in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 80.36% and 91.07%, respectively, and there were differences between two groups (P < 0.05). After treatment, uterine volume, fibroid volume, E2, P, and FSH in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Gongliuxiao Capsules combined with methyltestosterone and mifepristone has clinical curative effect in treatment of menopause uterine fibroids, and can significantly reduce fibroid volume, also can lower the levels of E2, P, and FSH, which has a certain clinical application value.
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