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[摘要]
目的 探讨痰热清注射液联合异丙托溴铵治疗颅脑损伤后肺部感染的临床疗效。方法 选取2014年2月-2015年3月屯昌县人民医院收治的颅脑损伤合并肺部感染患者200例,随机分为对照组和治疗组,每组100例。对照组在抗菌治疗的基础上使用异丙托溴铵气雾剂,2揿/次,3次/d。治疗组在对照组治疗基础上雾化吸入痰热清注射液,将痰热清注射液10mL加入到生理盐水10 mL中进行雾化吸入,2次/d。两组均连续治疗4周。观察两组的临床疗效,同时比较治疗前后两组氧分压(pO2)、二氧化碳分压(pCO2)、血氧饱和度(SpO2)、氧合指数(pO2/FiO2)的变化。比较两组感染控制率、感染控制时间、重症监护时间和住院时间。结果 治疗后,对照组和治疗组总有效率分别为70.0%、90.0%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组pO2、SaO2、pO2/FiO2显著升高,pCO2显著降低,同组治疗前后差异均有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组的感染控制率明显高于对照组,治疗组感染控制时间、重症监护时间都短于对照组,两组比较差异有统计学意义(P<0.05)。结论 痰热清注射液联合异丙托溴铵治疗颅脑损伤后肺部感染具有较好的临床疗效,能缩短感染控制时间,提高感染控制率,具有一定的临床推广应用价值。
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[Abstract]
Objective To observe the clinical effect of Tanreqing Injection combined with ipratropium bromide in treatment of pulmonary infection after craniocerebral injury. Methods Patients (200 cases) with pulmonary infection after craniocerebral injury in the People's Hospital of Tunchang County from February 2014 to March 2015 were randomly divided into control (n=100) and treatment (n=100) groups. The patients in the control group were given Ipratropium Bromide Aerosol on the basis of antimicrobial treatment, 2 presses/time, three times daily. The patients in the treatment group were aerosol inhalation administered with Tanreqing Injection on the basis of the control group, 10 mL added into normal saline 10 mL, twice daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of pO2, pCO2, SpO2, and pO2/FiO2 in two groups before and after treatment were compared. The infection control rate, infection control time, intensive care time, and hospital stays time in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 70.0% and 90.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, pO2, SaO2, and pO2/FiO2 in two groups were significantly increased, pCO2 was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, infection control rate in the treatment group was higher than that in the control group, and infection control time, intensive care time in the treatment group were shorter than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Tanreqing Injection combined with ipratropium bromide has clinical curative effect in treatment of pulmonary infection after craniocerebral injury, and can shorten infection control time, also can improve infection control rate, which has a certain clinical application value.
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