目的 观察麝香保心丸联合氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床疗效。方法 选取2013年1月-2014年1月北京市海淀区花园路社区卫生服务中心收治的高血压合并冠心病患者102例,根据随机数字表法分为对照组和治疗组,每组各51例。对照组患者口服氨氯地平阿托伐他汀钙片,1片/次,1次/d;治疗组患者在对照组基础上口服麝香保心丸,2粒/次,3次/d。两组均治疗6个月。观察两组患者降压和心绞痛改善的临床疗效,并对比两组患者在治疗前后的血压、不良反应发生率。结果 治疗后,对照组和治疗组患者降压总有效率分别为78.4%、92.2%,两组降压总有效率比较差异具有统计学意义(P<0.05);治疗后,对照组和治疗组患者心绞痛改善总有效率分别为76.5%、86.3%,两组心绞痛改善总有效率比较差异具有统计学意义(P<0.05)。治疗后,两组患者收缩压、舒张压均显著降低,同组治疗前后差异具有统计学意义(P<0.05);治疗组收缩压、舒张压下降的更为明显,但两组比较差异无统计学意义。治疗后,对照组和治疗组患者的不良反应发生率分别为9.8%、7.8%,两组不良反应发生率比较无统计学意义。结论 麝香保心丸联合氨氯地平阿托伐他汀钙片治疗高血压合并冠心病具有良好的疗效,不良反应较少,值得在临床上推广使用。

Objective To observe the effect of Shexiang Baoxin Pills combined with Amlodipine Besylate and Atorvastatin Calcium Tablets in treatment of hypertension with coronary heart disease. Methods Patients (102 cases) with hypertension with coronary heart disease in Beijing Haidian District Huayuan Road Community Health Service Center from January 2013 to January 2014 were divided into control and treatment groups according to the random number table method, and each group had 51 cases. The patients in the control group were po administered with Amlodipine Besylate and Atorvastatin Calcium Tablets, 1 tablet/time, once daily. The patients in the treatment group were po administered with Shexiang Baoxin Pills on the basis of control group, 2 pills/time, three times daily. The patients in two groups were treated for 6 months. After treatment, the clinical efficacies of anti-hypertension and improvement of angina pectoris were observed, and blood pressure and the incidence of adverse reactions in two groups were compared before and after treatment. Results After treatment, the efficacies of anti-hypertension and improvement of angina pectoris in the control and treatment groups were 78.4%, 92.2%, and 76.5%, 86.3%, respectively, and there were differences between two groups (P < 0.05). After treatment, systolic and diastolic blood pressures in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly lower than those in the control group, but there were no difference between two groups. After treatment, incidence of adverse reactions in the control and treatment groups were 9.8% and 7.8%, respectively, but there were no differences between two groups. Conclusion Shexiang Baoxin Pills combined with Amlodipine Besylate and Atorvastatin Calcium Tablets has good curative effect in treatment of hypertension with coronary heart disease, and less adverse reactions, which has a certain clinical application value.