目的 探讨丹红注射液致药品不良反应(ADR)的特点及相关因素,为临床合理用药提供参考。方法 检索2005—2015年中国学术期刊(网络版,CNKI)、万方数字化期刊全文库、中文科技期刊全文数据库(维普)报道的丹红注射液致ADR的文献,并进行统计、分析。结果 丹红注射液引发的ADR女性明显多于男性,年龄多集中在51~70岁,以全身损伤、皮肤损伤较为多见,所占构成比分别为22.6%、36.9%。在用药10~30 min出现的例数最多,占41.3%。给药途径均为注射给药,给药剂量为20 mL出现的ADR最多,占总人数的58.9%。结论 临床应加强丹红注射液的合理使用,尽量避免或减少其所致ADR的发生。

Objective To investigate the characteristics and related factors of adverse drug reactions (ADR) induced by Danhong Injection, and provide reference for clinical rational use of drugs. Methods China Journal Full-text Database (CNKI), Wangfang Database, Chinese Science and Technology Journal Full-text Database (VIP), etc were retrieved from 2005 to 2015, and the documents of ADR induced by Danhong Injection were analyzed and discussed. Results Women with ADR induced by Danhong Injection were more than men, and more were focused on 51—70 years old. The main ADR of Danhong Injection was systemic injury (22.6%) and skin injury (36.9%). The most cases (41.3%) occured in the medication during 10—30 min. The administration dosage was parenteral administration. The most cases (58.9%) occured with the administration dosage of 20 mL. Conclusion The rational use of Danhong Injection should be strengthened, and to avoid or reduce the occurrence of adverse reactions.

黑龙江省教育厅科学技术研究项目(12541571)