目的 评价2010—2014年天津市肿瘤医院氟尿嘧啶类药物的使用情况。方法 调取天津市肿瘤医院2010—2014年氟尿嘧啶类药物的相关用药信息,对药物剂型、使用金额、用药频度(DDDs)、日均费用(DDC)及药品排序比(B/A)进行统计分析。结果 2010—2014年氟尿嘧啶类药物的总使用金额和DDDs逐年增长。卡培他滨片、替吉奥胶囊、氟尿嘧啶注射液和氟尿嘧啶植入剂的使用金额呈逐年递增。替加氟注射液和注射用氟脲苷的使用金额连续5年递减。从排序来看,卡培他滨片、氟尿嘧啶植入剂、替吉奥胶囊连续4年排名前3位。卡培他滨的DDDs排名持续居于首位。口服剂型的使用金额构成比和DDDs构成比持续上涨,普通注射剂的使用金额构成比及DDDs构成比均明显下降。氟尿嘧啶类药物的DDC及排序相对稳定,大部分氟尿嘧啶类药物的B/A值接近于1.00,表明使用金额与使用频度的同步性较好。结论 天津市肿瘤医院氟尿嘧啶类药物使用合理,符合安全、有效、经济、方便的原则。

Objective To investigate the utilization of fluorouracil drugs in Tianjin Cancer Hospital from 2010 to 2014. Methods The utilization information of fluorouracil drugs in Tianjin Cancer Hospital from 2010 to 2014 was extracted, and the dosage form of drugs, consumption sum, defined daily doses (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) were analyzed statistically. Results From 2010 to 2014, the total consumption sums and DDDs of fluorouracil drugs were increasing year by year. The consumption sums of Capecitabine Tablets, Tegafur Gimeracil Oteracil Potassium Capsules, Fluorouracil Injection, and Fluorouracil Implants increased year by year, while the consumption sums of Tegafur Injection and Floxuridine for injection decreased progressively for five years. From the terms of sequences, Capecitabine Tablets, and Tegafur Gimeracil Oteracil Potassium Capsules ranked the Top 3 for four years. DDDs of Capecitabine Tablets ranked the first, persistently. The consumption sums and DDDs constituent ratios of oral formulations continued rising, and those of ordinary injection decreased obviously. DDC and sequences of fluorouracil drugs were relatively stable. B/A of most fluorouracil drugs was closed to 1.00, indicating that the synchronism was better. Conclusion The utilization of fluorouracil drugs in Tianjin Cancer Hospital is reasonable, according with the principle of safety, effectiveness, economy and convenience.