目的 观察固肾安胎丸联合盐酸利托君治疗先兆早产的临床疗效。方法 选择2014年6月—2015年6月四会市妇幼保健院妇产科收治的先兆早产患者102例,随机分为对照组和治疗组,每组各51例。对照组静脉滴注盐酸利托君注射液,100 mg用生理盐水500 mL稀释,直至达到预期效果。患者宫缩停止后,继续使用12 h,在停止静脉滴注前30 min用口服盐酸利托君片来巩固治疗。治疗组在对照组基础上口服固肾安胎丸,6 g/次,3次/d。两组均连续治疗2周。观察两组的保胎成功率、宫缩抑制显效时间、累积用药时间、孕期延长时间、自然分娩率,同时比较两组在治疗过程中的不良反应发生率。结果 治疗后,对照组和治疗组的保胎成功率分别为70.6%、94.1%,自然分娩率分别为43.1%、76.5%,两组比较差异具有统计学意义(P<0.05)。治疗组宫缩抑制显效时间、累积用药时间均显著短于对照组,孕期延长时间长于对照组,两组比较差异有统计学意义(P<0.05)。对照组和治疗组的不良反应发生率分别为29.4%、7.8%,两组比较差异有统计学意义(P<0.05)。结论 固肾安胎丸联合盐酸利托君治疗先兆早产具有很好的疗效,能够提高患者的保胎成功率,有利于孕妇自然分娩,具有一定的临床推广应用价值。

Objective To observe the clinical curative effect of Gushen Antai Pills combined with ritodrine hydrochloride in treatment of threatened premature labor. Methods Patients (102 cases) with threatened premature labor in Department of Obstetrics and Gynecology of Maternity and Child Care Hospital in Sihui City from June 2014 to June 2015 were randomly divided into control and treatment groups, and each group had 51 cases. The patients in the control group were iv administered with Ritodrine Hydrochloride Injection until the desired effect was achieved, 100 mg added into normal saline 500 mL. When the contractions stopped, Ritodrine Hydrochloride Injection was used continuously for 12 h, and the patients were po administered with Ritodrine Hydrochloride Tablets 30 min before stop the intravenous drip to consolidate therapy. The patients in the treatment group were po administered with Gushen Antai Pills on the basis of the control group, 6 g/time, three times daily. The patients in two groups were treated for 14 d. After treatment, success rate of tocolysis, contractions suppression time, cumulative duration time, prolong pregnancy time, and natural births rate in two groups were observed, at the same time, the incidence of adverse reactions in two groups during the process of treatment were compared. Results After treatment, the success rate of tocolysis in the control and treatment groups were 70.6% and 94.1%, the natural births rate in two groups were 43.1% and 76.5% respectively, and there were differences between two groups (P< 0.05). The contractions suppression time and cumulative duration time in the treatment group were shorter than those in the control group, and the prolong pregnancy time was longer than that in the control group, and there were differences between two groups (P< 0.05). The incidence of adverse reactions in control and treatment groups were 29.4% and 7.8%, respectively, and there were differences between two groups (P< 0.05). Conclusion Gushen Antai Pills combined with ritodrine hydrochloride has clinical curative effect in treatment of threatened premature labor, and can improve the patient's success rate of tocolysis, also be helpful for pregnant women to natural childbirth, which has a certain clinical application value.