目的 分析天津市肿瘤医院抗菌药物的使用情况,为促进临床合理用药提供依据。方法 调取2010—2014年天津市肿瘤医院抗菌药物的相关信息,对品规、销售金额、用药频度(DDDs)、日均费用(DDC)及药品排序比(B/A)进行统计分析。结果 2010—2014年,抗菌药物的品规数显著减少,销售金额2010—2012年先下降,然后呈现上升的趋势,头孢菌素类、碳青霉烯类与抗真菌药物的DDDs逐年上升,以碳青霉烯类增速最快。DDDs排名前10位的抗菌药物中,绝大多数药物的DDC超过100。绝大多数抗菌药物的B/A基本接近于1,表明大多数药物同步性较好。结论 天津市肿瘤医院抗菌药物的使用日趋合理,但碳青霉烯类药物的使用率日渐增高,应加强监督管理。

Objective To analyze the utilization of antimicrobial drugs in Tianjin Cancer Hospital, and to provide reference for rational use of drugs in clinic. Methods The utilization information of antimicrobial drugs in Tianjin Cancer Hospital from 2010 to 2014 was extracted, and the variety and specification numbers, consumption sum, defined daily doses (DDDs), defined daily cost (DDC) and drug sequence ratio (B/A) were analyzed statistically. Results The variety and specification numbers of antibacterial drugs were decreased from 2010 to 2014. The consumption sum decreased from 2010 to 2012, and increased from then on. DDDs of cephalosporins, carbapenems and antifungal agents increased year by year, and carbapenems increased most rapidly. DDC of most drugs exceed 100 in antimicrobial drugs with top 10 DDDs. B/A of most antimicrobial drugs closed to 1.00, indicating that the synchronism was better. Conclusion The use of antimicrobial drugs is becoming more rational in Tianjin Cancer Hospital. However, the use of carbapenems increase rapidly, which needs further efforts to strengthen the management.