目的 了解武汉大学人民医院抗癫痫药物的使用情况,为医护人员提供参考。方法 选取武汉大学人民医院2013年7月—2015年8月151份症状性癫痫病历进行回顾性分析,对患者的性别及年龄、病因、用药方案、抗癫痫药物的使用情况以及不良反应进行分类统计。结果 151例症状性癫痫患者中,男性多于女性;年龄多集中在51～64岁的患者;病因复杂,多集中在脑血管疾病、脑外伤、颅内感染3大原因;癫痫形式主要为全身性发作的强直阵挛性发作,抗癫痫治疗方案多采用单一用药的形式,而且丙戊酸钠和奥卡西平是临床上最常用的抗癫痫药物。结论 从药物流行病学角度考察了武汉大学人民医院神经内科抗癫痫药物的药物利用模式,对临床制定抗癫痫治疗方案具有积极的意义。

Objective To realize the utilizatin of of antiepileptic drugs in Department of Neurology in Renmin Hospital of Wuhan University, in order to provide a reference for medical staff. Methods Records of 151 patients with symptomatic epilepsy in Renmin Hospital of Wuhan University from July 2013 to August 2015 were extracted. Gender, age, etiology, and drug programs of patients, utilization of antiepileptic drugs, and adverse reactions were classified statistically. Results In patients (151 cases) with symptomatic epilepsy, men were more than women, and more were focused on 51 — 64 years old. Etiology was complex, and more were focused on cerebrovascular diseases, brain trauma, and intracranial infection. Generalized tonic-clonic seizure was the main form of epilepsy. A single drug was mostly used as drug programs for patients with symptomatic epilepsy. And sodium valproate and oxcarbazepine were the most common used drugs in the clinical practice. Conclusion The drug utilization pattern of antiepileptic drugs in Department of Neurology in Renmin Hospital of Wuhan University is discussed in the view of drug epidemiology, and it will have positive meaning for clinic to make antiepileptic medications.