目的 探讨清热散结胶囊联合异维A酸软胶囊治疗中、重度痤疮的临床疗效。方法 选取2014年10月—2015年6月重庆市红十字会医院(江北区人民医院)皮肤科收治的中、重度痤疮患者100例,随机分为对照组和治疗组,每组各50例。对照组在常规治疗基础上口服异维A酸软胶囊,10 mg/次,2次/d。治疗组在对照组治疗基础上口服清热散结胶囊5粒/次,3次/d,连用10～14 d,停7～10 d,再重复。两组均连续治疗3个月。观察两组的临床疗效,同时比较治疗前后两组皮肤病生活质量指数(DLQI)评分的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为74.0%、90.0%,两组总有效率比较差异有统计学意义(P<0.05)。治疗后两组DLQI量表评分均显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗后治疗组DLQI评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 清热散结胶囊联合异维A酸软胶囊治疗中、重度痤疮疗效显著,可显著提高患者的生活质量,且不良反应发生率较低,具有一定的临床推广应用价值。

Objective To investigate the curative effect of Qingre Sanjie Capsules combined with Isotretinoin Soft Capsules in treatment of medium and severe acne. Methods Patients (100 cases) with medium and severe acne in Department of Dermatology of Chongqing Red Cross Hospital (People's Hospital of Jiangbei District) from October 2014 to June 2015 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were po administered with Isotretinoin Soft Capsules on the basis of conventional treatment, 10 mg/time, twice daily. The patients in the treatment group were po administered with Qingre Sanjie Capsules on the basis of control group, 5 grains/time, three times daily, for 10—14 d, then stopped for 7—10 d, and repeated. The patients in two groups were treated for 3 monthes. After treatment, the clinical efficacy was evaluated, and the changes of dermatology life quality index (DLQI) in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.0% and 90.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, DLQI in two groups was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the DLQI in treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Qingre Sanjie Capsules combined with Isotretinoin Soft Capsules has clinical curative effect in treatment of medium and severe acne, and can significantly improve the life quality of patients with lower incidence of adverse reactions, which has a certain clinical application value.