目的 观察孟鲁司特联合免疫球蛋白治疗儿童腹型过敏性紫癜的疗效。方法 选取2013年6月—2014年12月在中山市中医院儿科接受治疗的腹型过敏性紫癜患者80例,随机分为对照组和治疗组,每组各40例。对照组静脉滴注冻干静注人免疫球蛋白,0.4 g/(kg·d)。治疗组在对照组治疗基础上口服孟鲁司特钠咀嚼片,2～5岁4 mg/d、6～11岁5 mg/d。两组均连续治疗10 d。观察两组的临床疗效,同时比较两组呕吐缓解时间、腹痛缓解时间、血便消失时间、皮疹开始消退时间、皮疹完全消退时间、住院时间。结果 治疗后,对照组和治疗组的总有效率分别为72.5%、92.5%,两组比较差异有统计学意义(P<0.05)。两组呕吐缓解时间、腹痛缓解时间相比差异无统计学意义。治疗组血便消失时间、皮疹开始消退时间、皮疹完全消退时间、住院时间均明显短于对照组,两组比较差异有统计学意义(P<0.05)。结论 孟鲁司特联合人免疫球蛋白治疗儿童腹型过敏性紫癜具有较好的临床疗效,可显著缩短各种临床症状消失时间,具有一定的临床推广应用价值

Objective To explore the clinical effect of montelukast combined with immunoglobulin in treatment of abdominal type allergic purpura in children. Methods Patients (80 cases) with abdominal type allergic purpura in Department of Pediatrics of Hospital of Traditional Chinese Medicine of Zhongshan from June 2013 to December 2014 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were iv administered with Human Immunoglobulin for intravenous injection, 0.4 g/kg·d. The patients in the treatment group were po administered with Montelukast Sodium Chewable Tablets on the basis of control group, 2 — 5 years old with 4 mg/d, 6 — 11 years old with 5 mg/d. The patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, relief times of vomiting and abdominal pain, bloody stools disappeared time, rash began to fade time, rash dissipated time, and time of hospital stay in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 72.5% and 92.5%, respectively, and there were differences between two groups (P < 0.05). After treatment, there was no statistically significant difference about relief times of vomiting and abdominal pain in two groups. Bloody stools disappeared time, rash began to fade time, rash dissipated time, and time of hospital stay in treatment group were shorter than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Montelukast combined with immunoglobulin has good clinical effect in treatment of abdominal type allergic purpura in children, and can significantly shorten the various clinical symptoms disappear time, which has a certain clinical application value.