目的 观察奥美沙坦酯氢氯噻嗪片治疗高血压的临床疗效。方法 选取2013年5月—2015年5月于北京市房山区良乡地区社区卫生服务中心就诊的120例高血压患者,用随机数表法分为对照组和治疗组,每组各60例。对照组口服氯沙坦钾片,1片/次,1次/d。治疗组口服奥美沙坦酯氢氯噻嗪片,1片/次,1次/d。两组均连续治疗8周。于患者治疗前1天和服药8周后进行两组患者的24 h动态血压监测,并测定心血管危险因素高敏C反应蛋白(hsCRP)、同型半胱氨酸(Hcy)水平。结果 治疗后治疗组的总有效率为85.0%,对照组的总有效率为73.3%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后治疗组24 h平均收缩压、24 h平均舒张压、白昼平均收缩压、白昼平均舒张压、夜间平均收缩压、夜间平均舒张压、白昼收缩压变异、白昼舒张压变异、夜间收缩压变异、夜间舒张压变异明显低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组hsCRP、Hcy水平显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组的降低程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论 奥美沙坦酯氢氯噻嗪片治疗高血压病不仅降压作用强,且血压变异性小,还能降低心血管危险因素,具有一定的临床推广应用价值。

Objective To explore clinical efficacy of Olmesartan Medoxomil Hydrochlorothiazide Tablets in treatment of hypertension. Methods Patients (120 cases) with hypertension in Beijing Fangshan District Liangxiang Community Health Service Center from May 2013 to May 2015 were divided into control and treatment groups using a random number table method, and each group had 60 cases. The patients in the control group were po administered with Losartan Potassium Tablets, 1 tablet/time, once daily. The patients in the treatment group were po administered with Olmesartan Medoxomil Hydrochlorothiazide Tablets, 1 tablet/time, once daily. The patients in two groups were treated for 8 weeks. At one day before treatment and 8 weeks after treatment, 24 h ambulatory blood pressure was monitored, and levels of cardiovascular risk factors of high-sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) were determined. Results After treatment, the efficacies in the control and treatment groups were 73.3% and 85.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, 24 h average systolic blood pressure, 24 h mean diastolic blood pressure, daytime mean systolic blood pressure, daytime mean diastolic blood pressure, and night mean systolic blood pressure, night mean diastolic blood pressure, and variations of daytime systolic blood pressure, daytime systolic blood pressure, daytime diastolic blood pressure, night systolic blood pressure, and night diastolic blood pressure were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were obviously lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, levels of hsCRP and Hcy in two groups were obviously decreased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Olmesartan Medoxomil Hydrochlorothiazide Tablets has the good clinical effect in treatment of hypertension, and it has not only strong antihypertensive effect, but also small blood pressure variability, also can reduce the cardiovascular risk factors,, which has a certain clinical application value.