目的 探究雷公藤多苷片联合阿魏酸钠治疗慢性肾小球肾炎的临床疗效。方法 收集2014年7月—2015年9月在沈阳市第四人民医院肾内科接受治疗的慢性肾小球肾炎患者84例,按照治疗方法不同分为对照组和治疗组,每组各42例。对照组静脉滴注注射用阿魏酸钠,0.3 g加入5%葡萄糖注射液250 mL,1次/d。治疗组在对照组治疗基础上口服雷公藤多苷片,20 mg/次,3次/d。两组患者均连续治疗1个月。观察两组患者的临床疗效,同时比较两组治疗前后血肌酐(Scr)、内生肌酐清除率(Ccr)、血尿素氮(BUN)、24 h尿蛋白的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为73.81%、90.48%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者Scr、BUN、24 h尿蛋白均较治疗前显著降低,Ccr显著升高,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 雷公藤多苷片联合阿魏酸钠治疗慢性肾小球肾炎的临床疗效显著,可有效改善患者的肾功能,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Tripterygium Glycosides Tablets combined with sodium ferulate in treatment of chronic glomerulonephritis. Methods Patients (84 cases) with chronic glomerulonephritis in Shenyang the Fourth Hospital of People from July 2014 to September 2015 were enrolled in this study. According to the different treatment plan, patients were divided into treatment group (42 cases) and control group (42 cases). The patients in the control group were iv administered with Sodium Ferulate for injection, 0.3 g added into 5% glucose injection (250 mL), once daily. The patients in the treatment group were po administered with Tripterygium Glycosides Tablets on the basis of control group, 20 mg/time, three times daily. The patients in two groups were treated for 1 month. After treatment, the clinical efficacy were evaluated, and the changes of Scr, Ccr, BUN, and 24 h urine protein before and after treatment in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.81% and 90.48%, respectively, and there were differences between two groups (P < 0.05). After treatment, Scr, BUN, and 24 h urine protein in two groups were significantly decreased, Ccr was significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Tripterygium Glycosides Tablets combined with sodium ferulate has clinical curative effect in treatment of chronic glomerulonephritis, and can effectively improve the kidney function of patients, which has a certain clinical application value.