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[摘要]
目的 探讨羟基脲致不良反应(ADR)发生的一般规律和特点,为临床合理用药提供参考。方法 检索中国期刊全文数据库(CNKI)、万方数字化期刊全文库、中文科技期刊全文数据库(维普)等数据库建库至2015年9月报道的羟基脲致ADR的文献,并进行分析和讨论。结果 羟基脲引起的不良反应共52例,其中男性明显多于女性,年龄多集中于41~80岁;慢性粒细胞白血病发生的ADR例数最多;有服用当天或短时间内就出现的ADR,服用超过3年的患者出现ADR占比最大,为69.23%;羟基脲引发的ADR以皮肤器官损害为主,其中皮肤溃疡所占比例最大,为82.69%。结论 羟基脲引发的ADR较为常见,临床使用时应及时处理,以确保患者用药安全。
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[Abstract]
Objective To investigate the general regularity and characteristics of adverse drug reaction (ADR) induced by hydroxycarbamide, and to provide the references for the rational use of drugs in clinic. Methods China Journal Full-text Database (CNKI), Wanfang Database, Chinese Science and Technology Journal Full-text Database (VIP), and other databases were retrieved from database foundation to September 2015, and the literature involving cases were analyzed and discussed. Results A total of 52 cases reduced by hydroxycarbamide were analyzed, in which men with ADR induced by hydroxycarbamide were more than women, and the ages of patients were mainly 41 — 80 years old. Patients with chronic granulocytic leukemia had the most ADR cases. There were ADR happened in the same day or within a short time, while the most cases (69.23%) occurred in the medication over three years. ADR induced by hydroxycarbamide mainly were skin system, in which skin ulcer took the most ratios (82.69%). Conclusion ADR induced by hydroxycarbamide is common in clinic. The using of hydroxycarbamide should be treated promptly, to ensure the medication safety.
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