目的 探讨百乐眠胶囊联合氟哌噻吨美利曲辛片治疗老年冠心病患者焦虑的疗效,为临床提供参考。方法 选取2011年1月—2014年6月陕西省中医医院收治的112例老年冠心病伴有焦虑症的患者,随机分为对照组(56例)和治疗组(56例)。两组均给予常规药物治疗冠心病,对照组给予氟哌噻吨美利曲辛片,1片/次,2次/d。治疗组在对照组的基础上加用百乐眠胶囊,4粒/次,2次/d。两组患者均连续治疗14 d。观察两组的临床疗效,比较两组患者焦虑评分、血脂变化情况。结果 治疗后,对照组和治疗组的总有效率分别为73.2%、92.9%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者焦虑评分均明显降低,差异具有统计学意义(P<0.05);并且治疗组焦虑评分降低程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平均下降(P<0.05),并且治疗组血脂降低程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 百乐眠胶囊联合氟哌噻吨美利曲辛片治疗老年冠心病伴有焦虑症患者,可显著改善临床症状,缓解焦虑,降低血脂水平,减少不良反应发生率,具有较大的临床借鉴意义。

Objective To evaluate curative effect of Bailemian Capsules combined with flupentixol and melitracen in treatment of senile coronary heart disease with anxiety symptoms, and provide reference for clinic. Methods Patients (112 cases) of senile coronary heart disease with anxiety symptoms in Shaanxi Provincial Chinese Medicine Hospital from January 2011 to June 2014 were randomly divided into control group (56 cases) and treatment group (56 cases). Two groups were given conventional drug treatment of coronary heart disease. Patients in control group were po administered with Flupentixol and Melitracen Tablets, 1 tablet/time, twice daily. Patients in treatment group were po administered with Bailemian Capsules 4 capsules/time on the basis of control group, twice daily. The patients in two groups were treated for 14 d. After treatment, the efficacy was evaluated, and anxiety scores and changes of blood lipid in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 73.2% and 92.9%, respectively, and there were differences between two groups (P < 0.05). After treatment, anxiety scores in two groups were obviously decreased, and the difference was statistically significant in the same group (P < 0.05). The reducing degrees in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TG, TC, and LDL-C were significantly decreased (P < 0.05), and the observed indexes in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Bailemian Capsules combined Flupentixol and Melitracen Tablets has clinical curative effect in treatment of senile coronary heart disease with anxiety symptoms, and can significantly improve the clinical symptoms, relieve anxiety, decrease the levels of blood lipid, and reduce adverse reactions, which has a certain clinical application value.