目的 探讨益心舒胶囊联合胺碘酮治疗室性早搏的临床疗效。方法 选择2014年6月—2015年1月徐州市中心医院收治的室性早搏患者104例,按照治疗方法分为对照组(48例)和治疗组(56例)。对照组口服盐酸胺碘酮片,0.2 g/次,第1周3次/d,第2周2次/d,第3、4周1次/d。治疗组在对照组治疗的基础上口服益心舒胶囊,3粒/次,3次/d。两组均连续治疗4周。观察两组的临床疗效、室性早搏疗效和心电图疗效,同时比较两组治疗前后临床症状评分的变化。结果 治疗后,对照组和治疗组的临床疗效总有效率分别为83.33%、96.43%,室性早搏总有效率分别为72.92%、89.29%,心电图总有效率分别为77.08%、91.07%,两组比较差异均有统计学意义(P<0.05)。两组心悸不安、乏力气短、胸闷胸痛的症状评分均较治疗前显著下降,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 益心舒胶囊联合胺碘酮治疗室性早搏的临床疗效确切,可显著改善临床症状,且不良反应较小,具有一定的临床推广应用价值。

Objective To observe the clinical effect of Yixinshu Capsules combined with amiodarone in treatment of ventricular premature beat. Methods Patients (104 cases) with premature ventricular were enrolled in this study from June 2014 to January 2015. According to the different treatment plan, patients were divided into treatment group (56 cases) and control group (48 cases). The patients in the control group were po administered with Amiodarone Hydrochloride Tablets, 0.2 g/time, three times daily in the first week, twice daily in the second week, once daily in the third and fourth week. The patients in the treatment group were po administered with Yixinshu Capsules on the basis of control group, 3 grains/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy, ventricular premature beat efficacies, and electrocardiogram efficacies were evaluated; And the changes of clinical symptom scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 96.43%, respectively, and ventricular premature beat efficacies in two groups were 72.92% and 89.29%, electrocardiogram efficacies in two groups were 77.08% and 91.07%, and there were differences between two groups (P < 0.05). The symptom scores of heart palpitations, weakness, shortness of breath, and chest tightness of chest pain in two groups were significantly reduced; And the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Yixinshu Capsules combined with amiodarone has clinical curative effect in treatment of ventricular premature beat, and can significantly improve the clinical symptoms with less adverse reaction, which has a certain clinical application value.