介孔二氧化硅纳米粒(MSNs)具有良好生物相容性、有序介孔结构、比表面积大、表面易修饰性等特点,在很多生物医药领域显示出了极大的应用前景,尤其是基于MSNs的纳米药物输送体系被广泛用于各种药物的递送。主要介绍MSNs和可降解MSNs的制备,同时介绍了MSNs膜包被及官能团修饰在缓释控释药物中的应用,最后探讨了MSNs递进到中空介孔二氧化硅纳米粒(HMSNs)的更大的应用前景。

Mesoporous silica nanoparticles (MSNs) has the characteristics of good biocompatibility, ordered mesoporous structure, large surface area, and surface characteristics of easy modification, so that MSNs show the great application prospect in many biomedical field. Especially nano drug delivery system based on MSNs is widely used in all kinds of drug delivery. The preparation of MSNs and biodegradable MSNs are summarized in this paper. At the same time, the application of membrane coating and functional group modification of MSNs in slow-release and controlled release drug are introduced. More applications from MSNs to the hollow mesoporous silica nanoparticles (HMSNs) are discussed.

国家自然科学基金资助项目(81202565)