目的 了解天津市肿瘤医院麻醉药品的使用情况和变化趋势,为促进临床合理用药提供依据。方法 对2011—2014年天津市肿瘤医院麻醉药品的用量、销售金额、用药频度(DDDs)、日均药费(DDC)及药品排序比(B/A)等进行统计和分析。结果 2011—2014年麻醉药品的销售金额及构成比均逐年增加;芬太尼透皮贴剂的销售金额在各年度均占绝对优势并逐年上升。麻醉药品的DDDs排名比较稳定,芬太尼透皮贴剂的DDDs排名持续第1位。除盐酸吗啡注射液、硫酸吗啡片、磷酸可待因片、盐酸布桂嗪注射液、盐酸布桂嗪片与盐酸哌替啶注射液在2014年的DDC出现增长,其余麻醉药品的DDC基本稳定。硫酸吗啡缓释片、枸橼酸芬太尼注射液、磷酸可待因片的B/A都大于1,注射用盐酸瑞芬太尼与枸橼酸舒芬太尼注射液均小于1,其余药物的B/A均接近1。结论 天津市肿瘤医院麻醉药品的应用基本合理,但仍存在一些不足,还需进一步加强管理。

Objective To investigate the usage and variation tendency of narcotic drugs in Tianjin Cancer Hospital, in order to provide reference for rational drug use in clinic. Methods The utilization, consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) of narcotic drugs in Tianjin Cancer Hospital during 2011—2014 were calculated and analyzed. Results During 2011—2014, the consumption sum and constituent ratios of narcotic drugs increased year by year. The consumption sum of Fentanyl Transdermal Patches ranked the first, and increased year by year. The rank of DDDs was stable, and DDDs of Fentanyl Transdermal Patches ranked the first persistently. DDC of Morphine Hydrochloride Injection, Morphine Sulfate Tablets, Codeine Phosphate Tablets, Bucinnazine Hydrochloride Injection, Ucinnazine Hydrochloride Tablets, and Pethidine Hydrochloride Injection in 2014 increased, while DDC of others were stable. B/A of Morphine Sulfate Sustained Release Tablets, Fentanyl Citrate Injection, and Codeine Phosphate Tablets were above 1, while B/A of Remifentanil Hydrochloride for injection and Sufentanil Citrate Injection were lower than 1. The others were close to 1. Conclusion The utilization of narcotic drugs in Tianjin Cancer Hospital is rational on the whole, but there are still some problems, which needs further efforts to strengthen the management.