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[摘要]
目的 探讨生血宁片联合琥珀酸亚铁片治疗妊娠期缺铁性贫血的临床疗效。方法 选择2012年1月—2014年12月重庆市铜梁区中医院收治的妊娠期缺铁性贫血患者170例,随机分为对照组和治疗组,每组各85例。对照组患者在基础治疗的基础上口服琥珀酸亚铁片,2片/次,3次/d。治疗组患者在对照组基础上口服生血宁片,2片/次,3次/d。两组均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后血清铁(SI)、血红蛋白(Hb)、红细胞(RBC)、平均红细胞体积(MCV)、平均红细胞血红蛋白浓度(MCHC)和铁蛋白饱和度(TSAT)的变化。结果 治疗后,对照组和治疗组的总有效率分别为77.65%、88.24%,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患者Hb、RBC、MCV、MCHC、SI、TSAT水平均显著高于治疗前,同组治疗前后差异均具有统计学意义(P< 0.05);治疗后治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 生血宁片联合琥珀酸亚铁片治疗妊娠期缺铁性贫血临床疗效安全可靠,可显著改善患者贫血症状和相关指标,且未见严重不良反应,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Shengxuening Tablets combined with Ferrous Succinate Tablets in treatment of iron deficiency anemia during pregnancy. Methods Patients (170 cases) with iron deficiency anemia during pregnancy in Traditional Chinese Medicine Hospital. Tongliang, Chongqing from January 2012 to December 2014 were randomly divided into control and treatment groups, and each group had 85 cases. The patients in the control group were po administered with Ferrous Succinate Tablets on the basis of foundation treatment, 2 tablets/time, three times daily. The patients in the treatment group were po administered with Shengxuening Tablets on the basis of the control group, 2 tablets/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacies in two groups were compared, and Hb, RBC, MCV, MCHC, TSAT, and SI in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 77.65% and 88.24%, respectively, and there were differences between two groups (P < 0.05). After treatment, Hb, RBC, MCV, MCHC, SI, and TSAT in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Shengxuening Tablets combined with Ferrous Succinate Tablets has safe and reliable clinical curative effect in treatment of iron deficiency anemia during pregnancy, and can significantly improve the symptoms and indicators related to anemia, which has a certain clinical application value.
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