目的 观察舒眠胶囊联合米氮平治疗老年睡眠障碍的临床疗效。方法 选取2014年5月—2015年5月江油市人民医院神经内科收治的睡眠障碍患者112例,随机分为对照组和治疗组,每组各56例。对照组每晚睡前口服米氮平片,1片/次,1次/d。治疗组在对照组治疗基础上口服舒眠胶囊,3粒/次,2次/d。两组患者均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后匹兹堡睡眠质量指数(PSQI)、睡眠总时间、睡眠效率、睡眠潜伏期、快动眼(REM)潜伏期、夜间觉醒次数、觉醒总时间的变化。结果 治疗后,对照组和治疗组的总有效率分别为67.86%、89.29%,两组总有效率比较差异具有统计学意义(P< 0.05)。治疗后,两组睡眠总时间、睡眠效率、REM潜伏期均显著升高,PSQI评分、睡眠潜伏期、夜间觉醒次数、觉醒总时间均显著下降,同组治疗前后差异有统计学意义(P< 0.05);且治疗组这些指标的改善程度优于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 舒眠胶囊联合米氮平治疗老年睡眠障碍具有较好的临床疗效,可改善患者的睡眠质量,降低PSQI评分,具有一定的临床推广应用价值。

Objective To observe the clinical curative effect of Shumian Capsules combined with mirtazapine in treatment of elder sleep disorders. Methods Patients (112 cases) with elder sleep disorders in Department of Neurology of Jiangyou People's Hospital from May 2014 to May 2015 were randomly divided into control and treatment groups, and each group had 56 cases. The patients in the control group were po administered with Mirtazapine Tablets every night before going to bed, 1 tablet/time, once daily. The patients in the treatment group were po administered with Shumian Capsules on the basis of the control group, 3 grains/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of PSQI, total sleep time, sleep efficiency, sleep latency, REM incubation period, night awakening times, and awakening total time in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 67.86% and 89.29%, respectively, and there were differences between two groups (P < 0.05). After treatment, total sleep time, sleep efficiency, and REM incubation period were significantly increased, and PSQI, sleep latency, night awakening times, and awakening total time were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Shumian Capsules combined with mirtazapine has clinical curative effect in treatment of elder sleep disorders, and can improve the sleep quality of patients and reduce the PSQI scores, which has a certain clinical application value.