目的 探讨尿感宁颗粒联合左氧氟沙星治疗尿路感染的临床疗效。方法 收集2014年5月—2015年4月泸州医学院附属医院收治的尿路感染患者69例,随机分为对照组(37例)和治疗组(32例)。对照组静脉滴注盐酸左氧氟沙星氯化钠注射液,0.2 g/次,2次/d。治疗组在对照组的治疗基础上口服尿感宁颗粒,1袋/次,3次/d。两组均连续治疗7 d。观察两组的临床疗效,同时比较两组尿频、尿急、尿痛、发热等临床症状消失时间。比较两组治疗前后尿白细胞镜检个数和尿细菌培养情况。结果 治疗后,对照组和治疗组的总有效率分别为75.68%、93.75%,两组比较差异有统计学意义(P< 0.05)。治疗组尿频、尿急、尿痛和发热等临床症状消失时间均显著短于对照组,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患者尿白细胞镜检个数和尿细菌培养均显著降低,同组治疗前后差异具有统计学意义(P< 0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 尿感宁颗粒联合左氧氟沙星治疗尿路感染具有较好的临床疗效,可以明显改善患者的临床症状,能够有效清除细菌,具有一定的临床推广应用价值。

Objective To observe the clinical effect of Niaoganning Granule combined with levofloxacin in treatment of urinary tract infection. Methods Patients (67 cases) with urinary tract infection in Affiliated Hospital of Luzhou Medical University from May 2014 to April 2015 were randomly divided into control (n = 37 ) and treatment (n = 32 ) groups. The patients in the control group were iv administered with Levofloxacin Hydrochloride and Sodium Chloride Injection, 0.2 g/time, twice daily. The patients in the treatment group were po administered with Niaoganning Granule, 1 bag/time, three times daily. The patients in two groups were treated for 7 d. After treatment, the efficacy was evaluated, and disappeared time of clinical symptoms such as urinary frequency, urgency, urine pain, and fever in two groups were compared. The microscopic examination of the urine leukocyte and culture situation of urine bacteria in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 75.68% and 93.75%, respectively, and there were differences between two groups (P < 0.05). After treatment, disappeared times of clinical symptoms such as urinary frequency, urgency, urine pain, and fever in treatment group were shorter than those in control group, with significant difference between two groups (P < 0.05). The urine leucocyte number of microscopic examination and urine bacteria culture in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Niaoganning Granule combined with levofloxacin has clinical curative effect in treatment of urinary tract infection, can obviously improve the clinical symptoms, and can effectively remove bacteria, which has a certain clinical application value.