目的 探究脑血疏口服液联合尼莫地平治疗高血压脑出血的临床疗效。方法 回顾性分析2013年4月—2015年4月延安大学附属医院神经外科收治的86例行微创颅内血肿清除术的高血压脑出血患者的临床资料,按照治疗方法不同分为对照组和治疗组,每组各43例。所有患者均行微创颅内血肿清除术。对照组术后静脉泵入尼莫地平注射液,泵速1 mg/h,7 d后改为口服尼莫地平片,40 mg/次,3 次/d。治疗组在对照组治疗基础上口服脑血疏口服液,10 mL/次,3次/d。两组均连续治疗4周。观察两组的临床疗效,同时比较两组患者治疗前后神经功能缺损(NIHSS)评分、血肿量、血肿周围水肿量、白细胞介素(IL)-4、IL-6、IL-10、肿瘤坏死因子(TNF)-α的变化。结果 治疗后,对照组和治疗组的总有效率分别为74.42%、93.02%,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患者血肿量、血肿周围水肿量显著减少,NIHSS评分、IL-4、IL-6、IL-10和TNF-α均显著降低,同组治疗前后差异有统计学意义(P< 0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 脑血疏口服液联合尼莫地平治疗高血压脑出血具有很好的临床疗效,可降低炎症因子水平,促进神经功能的恢复,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Naoxueshu Oral Liquid combined with nimodipine in treatment of hypertensive cerebral hemorrhage. Methods The clinical data of 86 patients with hypertensive cerebral hemorrhage who were treated in Department of Neurosurgery of Affiliated Hospital of Yan'an University from April 2013 to April 2014 were retrospectively analyzed. The patients were divided into control and treatment groups according to the different therapeutic methods, and each group had 46 cases. All patients were performed minimally invasive removal of intracranial hematoma. The patients in the control group were continuous intravenous pumping Nimodipine Injection after the operation, with the dripping speed of 1 mg/h, once daily. After 7 d, they were po administered with Nimodipine Tablets, 40 mg/time, three times daily. The patients in the treatment group were po administered with Naoxueshu Oral Liquid on the basis of the control group, 10 mL/time, three times daily. The patients in two groups were treated for 7 d. After treatment, the efficacy was evaluated, and the changes of NIHSS scores, hematoma amount, edema volume around the hematoma, IL-4, IL-6, IL-10, and TNF-α in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 74.42% and 93.02%, respectively, and there were differences between two groups (P < 0.05). After treatment, hematoma amount and edema volume around the hematoma in two groups were reduced, and NIHSS scores, IL-4, IL-6, IL-10, and TNF-α were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). These observed indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Naoxueshu Oral Liquid combined with nimodipine has curative effect in treatment of hypertensive cerebral hemorrhage, and can reduce the level of inflammatory factors, also can promote the recovery of neural function, which has a certain clinical application value.