目的 探讨武汉大学人民医院消化内科院内获得性感染病原菌的分布、耐药性及危险因素分析。方法 选取2012年8月—2015年2月武汉大学人民医院消化内科院内获得性耐药菌感染的住院患者64例,对分离出的病原菌的分布、耐药性及危险因素分析进行分析。结果 检出耐药菌的标本主要来源于尿液和痰液;分离出的耐药菌菌株中革兰阳性菌20株、革兰阴性菌44株。革兰阳性菌除对利奈唑胺敏感外,其余均有不同程度的耐药;革兰阴性菌耐药严重;住院患者院内获得性感染的主要危险因素为年龄、手术和尿管。结论 临床医护人员应加强关注住院患者院内获得性耐药菌感染的相关危险因素,预防感染的发生,合理使用抗菌药物。

Objective To study the distribution, drug resistance and risk factors of pathogenic bacteria of hospital acquired infection in Department of Gastroenterology in Renmin Hospital of Wuhan University. Methods Inpatients (64 cases) with hospital acquired infection in Department of Gastroenterology in Renmin Hospital of Wuhan University from August 2012 to February 2015 were selected. The distribution, drug resistance and risk factors of pathogenic bacteria were analyzed. Results The specimens were mainly obtained from urine and sputum. There were 20 strains of Gram-positive bacteria, and 44 strains of Gram-negative bacteria. Gram positive bacteria were sensitive to linezolid, while they were variously resistant to other antibiotic drugs. The resistance of Gram-negative bacteria was serious. The main risk factors of hospital acquired drug resistance bacteria infection was age, surgery and urine tube. Conclusion Clinical medical staff should pay much more attention to related risk factors of pathogenic bacteria of hospital acquired infection, to prevent the happening of bacterial infection, and rationally use antibiotic drugs.

湖北省自然科学基金面上项目(2013CFB239)