目的 观察复方阿嗪米特联合莫沙必利治疗儿童功能性消化不良的临床疗效。方法 选取2011年12月—2014年10月延安市人民医院收治的功能性消化不良患儿80例,随机分为对照组和治疗组,每组各40例。对照组患儿餐前15 min口服枸橼酸莫沙必利片5 mg/次,3次/d。治疗组患儿在对照组基础上口服复方阿嗪米特肠溶片,2片/次,3次/d。两组患儿均连续治疗1个月。观察两组的临床疗效,同时比较治疗前后两组患儿上腹痛、餐后饱胀、上腹部灼烧感、嗳气的评分变化。结果 治疗后,对照组和治疗组的总有效率分别为75.0%、87.5%,两组比较差异有统计学意义(P< 0.05)。治疗后,两组上腹痛评分、餐后饱胀评分、上腹部灼烧感评分、嗳气评分均较治疗前显著降低,同组治疗前后差异有统计学意义(P< 0.05);治疗组这些指标评分的降低程度显著优于对照组,两组比较差异具有统计学意义(P< 0.05)。对照组和治疗组的不良反应发生率分别为10.0%、12.5%,两组不良反应发生率比较差异无统计学意义。结论 复方阿嗪米特联合莫沙必利治疗儿童功能性消化不良具有较好的临床疗效,可有效缓解各种功能性消化不良的临床症状,不良反应小,具有一定的临床推广应用价值。

Objective To observe the efficacy of compound azintamide combined with mosapride in treatment of functional dyspepsia of children. Methods Patients (80 cases) with functional dyspepsia in Yan'an People's Hospital from December 2011 to October 2014were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were po administered with Mosapride Citrate Tablets 15 min before a meal, 5 mg/time, three times daily. The patients in the treatment group were po administered with Compound Azintamide Enteric-coated Tablets on the basis of the control group, two tablets/time, three times daily. The patients in two groups were treated for 1 month. After treatment, the efficacy was evaluated, the changes of abdominal pain score, postprandial full bilge score, burning score, and belching score in two groups before and after treatment were compared. Results After the treatment, the efficacies in the control and treatment groups were 75.0% and 87.5%, respectively, and there was difference between two groups (P < 0.05). After treatment, abdominal pain score, postprandial full bilge score, burning score, and belching score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The reduction extent of these indicators score in the treatment group was better than those in the control group, with significant difference between two groups (P < 0.05). The incidence of adverse reactions in the control and treatment groups were 10.0% and 12.5%, respectively, and there was no difference between two groups. Conclusion Compound azintamide combined with mosapride has good clinical effect in treatment of functional dyspepsia of children, and can effectively relieve clinical symptoms of functional dyspepsia with less adverse reactions, which has a certain clinical application value.