目的 观察喜炎平注射液联合小儿豉翘清热颗粒治疗儿童急性上呼吸道感染的临床疗效和安全性。方法 选取2015年3月—2015年4月汉中市中心医院儿科进行治疗的急性上呼吸道感染患儿120例,随机分为对照组和治疗组,每组患儿各60例。对照组给予小儿豉翘清热颗粒,开水冲服,3次/d,饭后服用,不同年龄组用量不同,6个月～1岁患儿:1～2 g/次;1～3岁患儿:2～3 g/次;4～6岁患儿:3～4 g/次;7～9岁患儿:4～5 g/次。治疗组患者采用喜炎平注射液静脉滴注,1次/d,0.2～0.4 mL/kg,小儿豉翘清热颗粒的用法、用量同对照组。两组患儿均连续治疗5 d。观察两组的临床疗效,同时比较两组治疗前后主要症状、体征消失时间以及血清学指标。结果 治疗后治疗组和对照组患儿总有效率分别为96.67%、75.00%,两组总有效率比较差异具有统计学意义(P< 0.05)。治疗组患儿退热时间、腹泻消失时间、呕吐消失时间、咳嗽消失时间、鼻塞消失时间和咽痛消失时间均显著低于对照组患儿,两组比较差异均具有统计学意义(P< 0.05)。治疗后两组患儿hs-CRP、TNF-α和IL-6较治疗前显著改善,治疗前后比较差异具有统计学意义(P< 0.05);治疗后治疗组患儿hs-CRP、TNF-α和IL-6较对照组患儿有显著改善,两组比较差异具有统计学意义(P< 0.05)。两组患儿在治疗期间均未观察到不良反应。结论 喜炎平注射液联合小儿豉翘清热颗粒治疗儿童急性上呼吸道感染临床疗效好,起效快,未发现不良反应,具有一定的临床推广应用价值。

Objective To explore the clinical curative effect and safety of Xiyanping Injection combined with Xiaoer Chiqiao Qingre Granule in treatment of pediatric acute upper respiratory infection. Methods Patients (120 cases) with acute upper respiratory infection in Hanzhong Central Hospital from March 2015 to April 2015 were selected, and they were randomly divided into control group and treatment group, each group with 60 cases. The patients in the control group were po administered with Xiaoer Chiqiao Qingre Granule in boiling water after meals, 3 times daily. The amounts of drugs were corresponding with ages of children, such as six months-6 years children had 1-2 g/time; 1-3 years old, 2-3 g/time; 4-6 years old, 3-4 g/time; 7-9 years old, 4-5 g/times. The patients in treatment group were administered with Xiyanping Injection iv drip, 1 time daily, 0.2-0.4 mL/kg, and the usage of Xiaoer Chiqiao Qingre Granule was the same to control group. Two groups of children were treated for 5 d. The clinical efficacies of the two groups were observed, and the main symptoms, signs, and serology index were compared between two groups. Results The efficacies in the control and treatment groups after treatment were 96.67% and 75%, respectively, and there was difference between two groups (P < 0.05). The disappearing time of fever, diarrhea, vomiting, cough, stuffy nose, and sore throat in the treatment group was significantly lower than children in control group, and the difference between two groups was statistically significant (P < 0.05). IL-6, TNF-α, and hs-CRP were significantly improved in two groups after treatment, and the difference was statistically significant before and after treatment (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Adverse reactions were not observed in the two groups during the treatment period. Conclusion Xiyanping Injection combined with Xiaoer Chiqiao Qingre Granule has good clinical curative effect in treatment of pediatric acute upper respiratory infection, and can significantly improve the clinical symptoms with no significant adverse reactions, which has a certain clinical application value.