目的 探究标准桃金娘油肠溶胶囊联合头孢米诺治疗急性化脓性鼻窦炎的临床疗效。方法 选取2012年1月—2014年12月亳州市人民医院耳鼻喉科收治的急性化脓性鼻窦炎患者80例,随机分为对照组和治疗组,每组各40例。对照组患者静脉滴注注射用头孢米诺钠,1 g/次,加到20 mL生理盐水中,2次/d。治疗组在对照组基础上口服标准桃金娘油肠溶胶囊,1粒/次,3次/d。两组均连续治疗6周。观察两组的临床疗效,同时比较两组治疗前后鼻腔黏膜纤毛传输时间的变化。随访3个月,计算两组的复发率。结果 治疗后,对照组和治疗组的总有效率分别为77.5%、92.5%,两组比较差异有统计学意义(P< 0.05)。治疗1、6周后两组鼻腔黏膜纤毛传输时间均有明显下降,同组治疗前后差异具有统计学意义(P< 0.05);且治疗组的下降程度优于对照组,两组比较差异具有统计学意义(P< 0.05)。对照组和治疗组的复发率分别为15%、5%,两组比较差异具有统计学意义(P< 0.05)。结论 标准桃金娘油肠溶胶囊联合头孢米治疗急性化脓性鼻窦炎的具有较好的临床疗效,明显缩短了鼻腔黏膜纤毛传输时间,具有较高的临床推广应用价值。

Objective To investigate the clinical efficacy of Myrtol Standardized Enteric Coated Soft Capsules combined with cefminox in treatment of acute suppurative sinusitis. Methods Patients (80 cases) with acute suppurative sinusitis in Department of Otolaryngology of the People's Hospital of Bozhou from January 2012 to December 2014 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were iv administered with Cefminox Sodium for injection, 1 g/time which added into physiological saline 20 mL, twice daily. The patients in the treatment group were po administered with Myrtol Standardized Enteric Coated Soft Capsules on the basis of the control group, 1 grain/time, three times daily. The patients in two groups were treated for 6 weeks. After treatment, the efficacy was evaluated, the changes of nasal mucosa cilia transmission time before and after treatment in two groups were compared. Follow-up of 3 months, the recurrence rates in two groups were calculated. Results After the treatment, the efficacies in the control and treatment groups were 77.5% and 92.5%, respectively, and there was difference between two groups (P < 0.05). After treatment, nasal mucosa cilia transmission times in two groups were significantly reduced after 1 and 6 weeks, and the difference was statistically significant in the same group (P < 0.05). The reduced degree in the treatment group was better than that in the control group, with significant difference between two groups (P < 0.05). The recurrence rates in the control and treatment groups were 5% and 15%, respectively, and there was difference between two groups (P < 0.05). Conclusion Myrtol Standardized Enteric Coated Soft Capsules combined with cefminox has good clinical efficacy in treatment of acute suppurative sinusitis, and can significantly shorten the nasal mucosa cilia transmission time, which has high clinical application value.