目的 探讨麝香保心丸联合阿托伐他汀治疗急性心肌梗死的临床疗效。方法 选择2012年1月—2014年12月荆门市第二人民医院收治的急性心肌梗死患者120例,随机分为治疗组和对照组,每组各60例,对照组在基础治疗的基础上口服阿托伐他汀片80 mg/d。治疗组在对照组的基础上给予麝香保心丸,2丸/次,3次/d,两组患者均连续治疗10周。比较两组的临床疗效、并发症发生情况以及血浆中乳酸脱氢酶(LDH)、心肌钙蛋白(cTnT)、超氧化物歧化酶(SOD)及肌酸激酶同工酶(CK-MB)水平。结果 治疗组总有效率明显高于对照组,两组比较差异具有统计学意义(P< 0.05);治疗2周后,治疗组并发症发生率为33.33%,显著低于对照组,比较差异有统计学意义(P< 0.05);治疗24 h后,两组患者血浆中LDH、cTnT、SOD及CK-MB水平均显著高于治疗前,且两组比较差异有统计学意义(P< 0.05);治疗24 h后,治疗组的LDH、cTnT及CK-MB水平显著低于对照组,SOD水平显著高于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 麝香保心丸联合阿托伐他汀治疗急性心肌梗死具有较好的临床疗效,显著降低并发症发生率,值得临床推广。

Objective To investigate the clinical effect of Shexiang Baoxin Pills combined with atorvastatin in treatment of acute myocardial infarction. Methods Patients (120 cases) with acute myocardial infarction in Jingmen No. 2 People's Hospital from January 2012 to December 2014 were randomly divided into control and treatment groups. Each group had 60 cases. Patients in control group were po given Atorvastatin Tablets 80 mg/d on the basis of conventional therapy. Patients in treatment group were given Shexiang Baoxin Pills 2 pills/time, three times daily. The patients in two groups were treated for 8 weeks. The efficacy, occurrence of complications, lactic dehydrogenase (LDH), cardiac troponin (cTnT), superoxide dismutase (SOD), and creatine kinase isoenzyme (CK-MB) in plasma between patients of two groups were compared. Results The clinical efficacy in treatment group was higher than that in control group with significant difference (P < 0.05). After treatment for 2 weeks, the incidence of complications in treatment group was 33.33%, significantly lower than that of control group, and the difference was statistically significant (P < 0.05). After treatment for 24 h, the levels of LDH, cTnT, SOD, and CK-MB of two groups were significantly higher than those before treatment with significant differences (P < 0.05). The levels of LDH, cTnT, and CK-MB in treatment group were significantly lower than those of control group, and the level of SOD was significantly higher than that in control group, with significant difference (P < 0.05). Conclusion Shexiang Baoxin Pills combined with atorvastatin has good efficacy in treatment of acute myocardial infarction, and also can reduce the incidence of complications, which has a certain clinical application value.