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[摘要]
目的 探讨免疫球蛋白联合去乙酰毛花苷注射液治疗老年扩张型心肌病的临床疗效。方法 选取2010年1月—2014年12月榆林市第一医院心血管内科收治的老年扩张型心肌病患者200例,随机分为对照组和治疗组,每组各100例。两组患者均接受利尿剂等常规基础治疗。对照组患者静脉滴注去乙酰毛花苷注射液,0.5 mg/次,2次/d;治疗组在对照组基础上静脉滴注静注人免疫球蛋白,400 mg/d。两组均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后左心室射血分数(LVEF)、舒张早期血流峰值速度(EPFV)、充盈早期速率/晚期速率(E/A)、舒张晚期血流峰值速度(APFV)、左心室收缩末期容积(LVESV)、左心室质量(LV)、左心室舒张末期容积(LVEDV)、心胸比(CTR)、IgG抗体的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为69.00%、85.00%,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患者LVEF、E/A、EPFV显著升高,APFV、LVESV、LVEDV、LV、CTR、IgG抗体均显著降低,同组治疗前后差异具有统计学意义(P< 0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 免疫球蛋白联合去乙酰毛花苷注射液治疗老年扩张型心肌病具有较好的临床疗效,可显著改善患者的心功能,降低IgG抗体水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the curative effect of human immunoglobulin combined with Deslanoside Injection in treatment of elder dilated cardiomyopathy. Methods Patients (200 cases) with dilated cardiomyopathy in Department of Cardiovascular Internal Medicine of the First Hospital of Yulin from January 2010 to December 2014 were randomly divided into control and treatment groups, and each group had 100 cases. Patients in two groups were given regular basic treatment such as diuretics. The patients in the control group were iv administered with Deslanoside Injection, 0.5 mg/time, twice daily. The patients in the treatment group were iv administered with Human Immunoglobulin (pH 4) for iv injection, 400 mg/d. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of LVEF, EPFV, E/A, APFV, LVESV, LV, LVEDV, CTR, and IgG antibody in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 69.00% and 85.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, LVEF, E/A, and EPFV in two group were significantly increased, and APFV, LVESV, LVEDV, LV, CTR, and IgG antibody were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Human immunoglobulin combined with Deslanoside Injection has good clinical efficacy in treatment of elder dilated cardiomyopathy, and can significantly improve cardiac function, also can decrease the level of IgG antibody, which has a certain clinical application value.
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