人类免疫缺陷病毒(HIV)-1 侵入抑制剂能抑制HIV 进入靶细胞,在最初环节抑制病毒的传播.具有高活性、较好药物代谢性质的肽及肽类似物不断被发现,并成为抗HIV 药物研究的热点.根据HIV-1 进入靶细胞的3 个步骤可将侵入抑制剂分为黏附抑制剂、辅助受体结合抑制剂和融合抑制剂,并对其研发策略和研究进展进行综述.

Human immunodeficiency virus (HIV)-1 entry inhibitors can inhibit HIV entering the target cells, and restrain the spreading of virus at the first part. Peptide and peptide analogue with high activity, good metabolic characteristics continue to be discovered, and they become the research hot spot of anti-HIV drugs. According to three steps of HIV-1 into the target cells, HIV-1 entry inhibitors are divided into adhesion antagonists, auxiliary receptor inhibitors, and fusion inhibitors. Research strategies and recent insights of those peptides as well as their analogs are summarized.

黑龙江省教育厅科学技术研究项目(12521200);哈尔滨医科大学药学院大学生创新基金项目