目的 分析天津市河北区铁东路街社区卫生服务中心抗高血压药物的应用情况和趋势,为临床合理用药提供参考.方法 对2012-2014 年抗高血压药物的应用品种、销售金额、用药频度(DDDs)及日均药费(DDC)进行统计和分析.结果 2012-2014 年抗高血压药物的销售金额呈逐年上升趋势;该院抗高血压药物有钙通道阻滞剂(CCB)、血管紧张素Ⅱ受体拮抗剂(ARB)、血管紧张素转换酶抑制剂(ACEI)、β-受体阻滞剂(β-RB)、利尿药及复方制剂;2012-2014 年销售金额及构成比的排序均为CCB、ARB、ACEI、β-RB、利尿药及复方制剂;CCB 中的硝苯地平在2012 年位居销售金额及DDDs的首位;CCB 中的左旋氨氯地平在2013、2014 年位居销售金额及DDDs 排序首位;ARB 中缬沙坦的DDC 在2012-2014年均为最高.结论 天津市河北区铁东路街社区卫生服务中心抗高血压药物以CCB、ARB、ACEI、β-RB 为主,应用基本合理,从用药趋势看CCB、ARB 具有良好的应用前景.

Objective To analyze the application and trend of antihypertensive drugs in Tiedong Road Community Health Service Center of Heibei District in Tianjin, to provide reference for clinical rational use. Methods The categories, consumption sum, defined daily doses (DDDs), and daily drug cost (DDC) of antihypertensive drugs were analyzed statistically. Results From 2012 to 2014, the consumption sum of antihypertensive drugs increased year by year. The antihypertensive drugs were calcium channel blockers (CCB), angiotensin Ⅱ receptor blockers (ARB), angiotensin converting enzyme inhibitors (ACEI), β-receptor blockers (β-RB), diuretics, and compound preparations. Sequences of consumption sum and constituent ratios from 2012 to 2014 were CCB, ARB, ACEI, β-RB, diureties, and compound preparations. Consumption sum and DDDs of nifedipine in CCB ranked the first in 2012. Consumption sum and DDDs of L-amlodipine in CCB ranked the first in 2013 and 2014. DDC of valsartan in ARB was the highest from 2012 to 2014. Conclusion The main antihypertensive drugs were CCB, ARB, ACEI, and β-RB in Tiedong Road Community Health Service Center of Heibei District in Tianjin. The application of antihypertensive drugs is basically rational. CCB and ARB have a good prospect of application from the trend of drug use.