目的 探究诺迪康联合脑蛋白水解物治疗脑梗死患者认知功能障碍的临床疗效.方法 选取2011 年4 月-2014 年4 月平顶山煤业集团总医院收治的脑梗死认知功能障碍的患者80 例,随机分为对照组和治疗组,每组各40 例.对照组在基础治疗上静脉滴注脑蛋白水解物注射液30 mL＋生理盐水250 mL,1 次/d.治疗组在对照组基础上口服迪诺康胶囊,2 粒/次,3 次/d.两组均连续治疗30 d.观察两组的临床疗效,同时比较两组患者在治疗前后简易智力状态检查量表(MMSE)评分、日常生活能力调查表(ADL)评分、躯体生活自理量表(PSMS)评分、工具性日常生活能力量表(IADLS)评分的变化.结果 治疗后,对照组和治疗组的总有效率分别为70.0%、80.0%,两组比较差异具有统计学意义(P< 0.05).治疗后,两组患者的MMSE 评分均较治疗前显著升高,ADL 评分、PSMS 评分、IDAL 评分均显著降低,同组治疗前后差异有统计学意义(P< 0.05);治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P< 0.05).结论 诺迪康联合脑蛋白水解物治疗脑梗死认知功能障碍具有较好的临床疗效,可改善患者的智力状态,提高其生活质量,具有一定的临床推广应用价值.

Objective To investigate the clinical efficacy of Nuodikang Capsules combined with Cerebroprotein Hydrolysate Injection in treatment of cognitive dysfunction after cerebral infarction. Method Patients (80 cases) with cognitive dysfunction after cerebral infarction in Pingdingshan Coal Group General Hospital from April 2011 to April 2014 were randomly divided into control and treatment groups. Each group had 40 cases. Patients in control group were iv administered with Cerebroprotein Hydrolysate Injection on the basis treatment, 30 mL added in 250 mL physiological saline, once daily. Patients in treatment group were po administered with Nuodikang Capsules, 2 grains/time, three times daily. Patients in two groups were treated for 30 d. After treatment, the efficacy was evaluated, and the scores of MMSE, ADL, PSMS, and IADLS in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 70.0% and 80.0%, respectively, and there were differences between two groups (P < 0.05). The MMSE scores in two groups were significantly reduced, and the scores of ADL, PSMS, and IADLS in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). Those observation indexes improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Nuodikang Capsules combined with Cerebroprotein Hydrolysate Injection has good effect in treatment of cognitive dysfunction after cerebral infarction, can improve the mental state of patients, and also can improve the quality of life, which has a certain clinical application value.