目的 对淄博市中心医院中药注射剂超说明书用药情况进行调查分析, 为临床合理用药提供参考。方法 随机抽取2014年淄博市中心医院使用中药注射剂的住院患者病历200份, 对中药注射剂的溶媒选择、用药剂量或浓度、用药疗程、超适应症用药等进行分析评价。结果 中药注射剂临床使用广泛。中药注射剂存在一定程度溶媒选择不当、超剂量、超浓度或超疗程用药等超说明书用药的情况, 超说明书用药处方占42%。结论 加强处方点评与反馈, 对超说明书用药进行有效干预, 促进中药注射剂的合理使用。

Objective To investigate the off-label use of traditional Chinese medicine (TCM) injection in Central Hospital of Zibo, and to provide reference for reasonable application of TCM injection. Methods In-patients (200 cases) using TCM injection in Central Hospital of Zibo in 2014 were randomly extracted, and the selection of solvent, drug dosage or concentration, course of medication, and ultra-indication of TCM injection were analyzed and evaluated. Results TCM injection were widely used in Central Hospital of Zibo. There was a certain degree of off-label use of drugs, including unreasonable choice of solvent, ultra-dosage, ultra-concentration, and ultra-course of medication. The prescription of off-label use of TCM injection accounted for 42%. Conclusion Prescription comments and feedback should be strengthened, and off-label use of TCM injection should be given effective intervention, to promote rational use of TCM injection.

山东省药学会临床药学奥赛康中青年科研资助项目(Sdpa-ask-2013-01)