目的 探讨选择性5-羟色胺再摄取抑制剂(SSRI)致药品不良反应(ADR)的规律和特点,为临床合理用药提供参考。方法 检索2004年1月－2014年12月中国期刊全文数据库(CNKI)、万方数字化期刊全文库、中文科技期刊全文数据库(维普)、中国医院知识总库(CHKD)等数据库报道的SSRI致ADR的文献,并进行分析和讨论。结果 SSRI引发的ADR女性明显多于男性,年龄多集中于41～60岁;抑郁症发生的ADR例数最多;在引发ADR的SSRI中,帕罗西汀的发生率最高;服药4周后出现ADR的例数最多,占30.5%;有25例联合用药,其中帕罗西汀联合用药的例数最多;SSRI引发的ADR以神经系统损害为主,占44.9%。结论 SSRI引发的ADR较为常见,临床使用时应及时处理,以确保患者用药安全。

Objective To explore the rules and characteristics of adverse drug reaction (ADR) induced by selective serotonin reuptake inhibitor (SSRI), and to provide the references for the rational use of drugs in clinic. Methods China Journal Full-text Database (CNKI), Wangfang Database, Chinese Science and Technology Journal Full-text Database (VIP), China Hospital Knowledge Database (CHKD), etc were retrieved from January 2004 to December 2014, and the literature involving cases were analyzed and discussed. Results Women with ADR induced by SSRI were more than men, and more were focused on 41 — 60 years old. Depression patients had the most ADR cases. In the varieties of SSRI, paroxetine had the highest ADR incidence. The most cases (30.5%) occured in the medication after 4 weeks. The cases of combination were 25, in which paroxetine had the most cases. ADR induced by SSRI mainly were nervous system (44.9%). Conclusion ADR induced by SSRI is common in clinic. The using of SSRI should be treated promptly, to ensure the medication safety.

国家自然科学基金资助项目(81403198)