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[摘要]
目的 观察醋酸甲羟孕酮联合克林霉素磷酸酯治疗产后子宫内膜炎的临床疗效。方法 选取2013年1月—2015年1月黄石市中心医院收治的产后子宫内膜炎患者150例,随机分为对照组和治疗组,每组各75例。对照组患者口服克林霉素磷酸酯片,2片/次,3次/d;治疗组在对照组治疗的基础上口服醋酸甲羟孕酮片,3片/次,3次/d。两组均连续治疗14 d。观察两组的临床疗效,同时比较两组患者腹痛感消失时间、炎症消失时间、白细胞恢复正常时间、体温恢复正常时间,比较两组血清肿瘤坏死因子(TNF-α)、C反应蛋白的变化。结果 治疗后,对照组和治疗组总有效率分别为77.33%、92.00%,两组总有效率比较差异具有统计学意义(P < 0.05)。治疗组患者腹痛感消失时间、炎症消失时间、白细胞恢复正常时间、住院时间和体温恢复正常时间均显著短于对照组患者,两组比较差异均有统计学意义(P < 0.05)。两组患者治疗后血清TNF-α和C反应蛋白水平较治疗前显著降低,同组治疗前后差异有统计学意义(P < 0.05);且治疗后治疗组的改善程度优于对照组,两组比较差异有统计学意义(P < 0.05)。结论 醋酸甲羟孕酮联合克林霉素磷酸酯治疗产后子宫内膜炎具有较好的临床疗效,可缩短临床症状改善时间,还可降低TNF-α、C反应蛋白水平,值得推广应用。
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[Abstract]
Objective To observe the clinical curative effect of medroxyprogesterone acetate combined with clindamycin phosphate in treatment of postpartum endometritis. Methods Patients (150 cases) with postpartum endometritis of Huangshi Central Hospital from January 2013 to January 2015, were randomly divided into control and treatment groups, and each group had 75 cases. The patients in control group were po administered with Clindamycin Phosphate Tablets, 2 tablets/time, three times daily. The patients in the treatment group were po administered with Medroxyprogesterone Acetate Tablets on the basis of the control group, 3 tablets/time, three times daily. Both groups were treated for 14 d. The clinical efficacies between two groups were observed after treatment. At the same time, extinction time of abdominal pain and inflammation, white blood cells recovery time, and body temperature recovery time in two groups were compared, while the changes of TNF-α and CRP in two groups were compared. Results The efficacies in the control and treatment groups were 77.33% and 92.00%, respectively, and there were differences between two groups (P < 0.05). After treatment, the disappear time of abdominal pain and inflammation, and back to normal time of white blood cells and body temperature in the treatment group were shorter than those in the control group, and there were differences between two groups (P < 0.05). After treatment, TNF-α and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Results Medroxyprogesterone acetate combined with clindamycin phosphate has the good clinical effect in treatment of postpartum endometritis, and can shorten the improvement time of clinical symptoms, and reduce the level of TNF-α and CRP, which is worth clinical promotion.
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