目的 探讨盐酸氯丙嗪联合帕洛诺司琼预防化疗药物致恶心呕吐的临床疗效。方法 2014年1月—2014年7月在襄阳市中心医院行高致吐性化疗药物的住院患者126例,随机分为对照组和治疗组,每组63例。对照组患者在化疗第1天,开始化疗前30 min静脉滴注盐酸帕洛诺司琼注射液,0.25 mg/次,1次/d,注射时间30 s以上。治疗组在对照组基础上肌肉注射盐酸氯丙嗪注射液25 mg/次。3周为1个化疗周期,两组在1个化疗周期后观察恶心、呕吐的控制率。结果 对照组和治疗组急性呕吐控制率分别为76.19%、84.13%,延迟性呕吐控制率分别为50.79%、63.49%,治疗组急性、延迟性呕吐控制率均显著高于对照组,两组比较差异具有统计学意义(P < 0.05)。对照组和治疗组急性恶心控制率分别为58.73%、77.78%,延迟性恶心控制率分别为49.21%、65.08%,两组比较差异具有统计学意义(P < 0.05)。对照组和治疗组急性食欲减退控制率分别为87.30%、90.48%,延迟性食欲减退控制率分别为84.12%、87.30%,两组比较差异无统计学意义。结论 盐酸氯丙嗪联合帕洛诺司琼预防化疗药物致恶心呕吐具有较好的临床疗效,且不会增加不良反应,值得临床推广应用。

Objective To explore the clinical effect of chlorpromazine hydrochloride combined with palonosetron in preventing nausea and vomiting induced by chemotherapy drugs. Methods Patients (126 cases) with malignant tumor receiving emetogenic chemotherapy in Xiangyang Central Hospital from January 2014 to July 2014 were randomly divided into control and treatment groups, and each group had 63 cases. The patients in the control group were iv administered with Palonosetron Hydrochloride Injection 30 min before chemotherapy at the first day of the chemotherapy, 0.25 mg/time, once daily, and the injection time was more than 30 s. The patients in the treatment group were im administered with Chlorpromazine Hydrochloride Injection at the basis of the control group, 25 mg/time. One course of treatment was 3 weeks, the control rates of nausea and vomiting were observed after one chemotherapy cycle. Results The acute vomiting control rates in the control and treatment groups were 76.19% and 84.13%, respectively, while delayed vomiting control rates in two groups were 50.79% and 63.49%, respectively. The acute and delayed vomiting control rates in treatment group were higher than those in the control group, and there were differences between two groups (P < 0.05). The acute nausea control rates in the control and treatment groups were 58.73% and 77.78%, respectively, while delayed nausea control rates in two groups were 49.21% and 65.08%, respectively, and there were differences between two groups (P < 0.05). The acute nausea control rates in the control and treatment groups were 87.30% and 90.48%, respectively, while delayed nausea control rates in two groups were 84.12% and 87.30%, respectively, and there was no difference between two groups. Conclusion Chlorpromazine hydrochloride combined with palonosetron has the good clinical effect in preventing nausea and vomiting induced by chemotherapy drugs, and will not increase adverse reactions, which is worth clinical promotion.