目的 探讨稳心颗粒联合曲美他嗪治疗慢性心力衰竭的临床疗效。方法 选取2013年1月—2014年5月邯郸市人民医院收治的慢性心力衰竭患者68例,随机分为对照组和治疗组,每组各34例。对照组在基础治疗上口服盐酸曲美他嗪片20 mg/次,3次/d。治疗组在对照组基础上口服稳心颗粒,1袋/次,3次/d。两组均连续治疗6个月。观察两组的临床疗效,同时比较左室舒张末期内径(LVEDd)、收缩末期内径(LVESD)、左心室射血分数(LVEF)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平变化。结果 治疗后,治疗后,对照组和治疗组总有效率分别为73.53%、91.18%,两组总有效率比较差异具有统计学意义(P < 0.05)。治疗后,两组LVEDd、LVESD、IL-6、TNF-α均较治疗前显著降低,LVEF显著升高,同组治疗前后差异有统计学意义(P < 0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P < 0.05)。结论 稳心颗粒联合美他嗪治疗慢性心力衰竭具有显著疗效,可改善患者心功能,降低IL-6、TNF-α炎性因子水平,具有一定的临床推广应用价值。

Objective To investigate the efficacy of Wenxin Granule combined with trimetazidine in treatment of chronic heart failure. Methods Patients (68 cases) with chronic heart failure in Handan People's Hospital from January 2013 to May 2014 were randomly divided into control and treatment groups. Each group had 34 cases. Patients in control group were po administered with Trimetazidine Dihydrochloride Tablets on the basis of foundation treatment, 20 mg/time, three times daily. Patients in treatment group were po administered with Wenxin Granules on the basis of control group, 1 bag/time, three times daily. Two groups were treated for 6 months. After treatment, the efficacy was evaluated, and the changes of LVEDd, LVESD, LVEF, IL-6, and TNF-α in two groups were compared. Results The efficacies in the control and treatment groups were 73.53% and 91.18%, respectively, and there were differences between two groups (P < 0.05). After treatment, LVEDd, LVESD, IL-6, and TNF-α in two groups were significantly reduced, but LVEF was significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Wenxin Granule combined with trimetazidine has the good clinical effect in treatment of chronic heart failure, and can improve cardiac function in patients, while can reduce the levels of IL-6 and TNF-α, which has a certain clinical application value.