目的 探讨丁苯酞联合阿司匹林治疗急性分水岭脑梗死的临床疗效。方法 选取2012年10月—2014年10月天津市宝坻区人民医院收治的急性分水岭脑梗死患者100例,随机分为对照组和治疗组,每组50例。对照组在对症治疗的基础上口服阿司匹林肠溶片,2片/次,3次/d。治疗组在对照组治疗的基础上口服丁苯酞软胶囊,2粒/次,3次/d。两组患者均连续治疗15 d。观察两组患者的临床疗效,同时比较两组治疗前后血脂水平、血糖、血流量、血压、神经功能缺损评分、Barthel指数的变化。结果 治疗后,对照组和治疗组总有效率分别为72.0%、94.0%,两组总有效率比较差异具有统计学意义(P < 0.05)。两组患者的TC、TG、LDL、血糖、收缩压、舒张压、神经功能缺损评分均较治疗前显著降低,血流量、Barthel指数均较治疗前显著升高,同组治疗前后差异有统计学意义(P < 0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P < 0.05)。结论 丁苯酞联合阿司匹林治疗急性分水岭脑梗死具有较好的临床疗效,能改善患者的神经功能缺损程度,提高患者的生活质量,值得临床推广应用。

Objective To observe the clinical effect of butylphthalide combined with aspirin in treatment of acute watershed cerebral infarction. Methods Patients (100 cases) with acute watershed cerebral infarction in Tianjin Baodi Hospital from October 2012 to October 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were po administered with Aspirin Enteric-coated Tablets on the basis of symptomatic treatment, 2 tablets/time, three times daily. The patients in the treatment group were po administered with Butylphthalide Soft Capsules on the basis of control group, 2 grains/time, three times daily. Two groups were treated for 15 d. After treatment, the efficacy was evaluated, and the changes of lipid levels, blood sugar, blood flow, blood pressure, neural function defect scale and Barthel index in two groups were compared. Results The efficacies in the control and treatment groups were 72.0% and 94.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, TC, TG, LDL, blood glucose, systolic pressure, diastolic blood pressure, and neural function defect scale in two groups were significantly reduced, blood flow and Barthel index was significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Butylphthalide combined with aspirin has the good clinical effect in treatment of acute watershed cerebral infarction, and can improve the nerve function defect degree, while also can improve the life quality of patients, which is worth clinical promotion.