目的 探讨盐酸米诺环素软膏治疗慢性牙周炎的临床疗效。方法 选取2013年8月—2014年8月遂宁市中心医院收治的80例慢性牙周炎患者共94颗患牙,随机分为对照组和治疗组,每组47颗患牙。两组患者均给予常规龈上洁治术及龈下刮治术等基础治疗。对照组患者在牙周袋内注入碘甘油。治疗组将盐酸米诺环素软膏放入患牙牙周袋内,直至溢出。两组患者每周1次,共4次。观察两组患者的临床疗效,同时比较两组牙周袋深度(PD)、菌斑指数(PLI)、牙周附着水平(AL)、龈沟出血指数(SBI)、C反应蛋白(CRP)及白介素-6(IL-6)的变化。结果 治疗后,对照组和治疗组总有效率分别为78.72%、95.74%,两组总有效率比较差异具有统计学意义(P < 0.05)。治疗后,两组的PD、PLI、AL、SBI均较同组治疗前显著降低,同组治疗前后差异有统计学意义(P < 0.05),且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P < 0.05)。治疗组CRP较治疗前显著降低,且治疗后显著低于对照组(P < 0.05)。结论 盐酸米诺环素软膏治疗慢性牙周炎疗效显著,能有效改善牙周炎症,同时对患者机体的系统炎症状态起到一定的缓解作用,值得推广应用。

Objective To investigate the effect of Minocycline Hydrochloride Ointment in treatment of chronic periodontitis. Methods A total of 94 teeth in 80 patients in Suining Central Hospital from August 2013 to August 2014 were randomly divided into control and treatment groups, and each group had 47 teeth. Two groups of patients were given foundation treatment such as conventional supragingival and subgingival curettage surgery. Patients in the control group were given iodine glycerin in the periodontal pocket. Patients in the treatment group were given Minocycline Hydrochloride Ointment in periodontal pockets until the overflow. Two groups of patients were given once a week, and a total of four times. After treatment, the efficacy was evaluated, and the changes of PD, PLI, AL, SBI, CRP, and IL-6 in two groups were compared. Results The efficacies in the control and treatment groups were 78.72% and 95.74%, respectively, and there were differences between two groups (P < 0.05). After treatment, PD, PLI, AL, and SBI in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). CRP in treatment group was significantly decreased, and it was lower than that in the control group (P < 0.05). Conclusion Minocycline Hydrochloride Ointment has significant effect in treatment of chronic periodontitis, and can effectively improve periodontal inflammation. At the same time, it plays a role on alleviating inflammation, which is worth clinical promotion.

国家自然科学基金资助项目(30973323)