2型糖尿病患病人数呈现快速增加的趋势,由其引发的认知功能障碍成为被关注的热点,但其发病机制尚不完全清楚.近年来一种2型糖尿病的“炎症学说”逐渐被越来越多的学者所提及,并且越来越多的研究发现某些因素能够介导神经炎症从而引发2型糖尿病脑病,将从小胶质细胞活化、外周细胞因子、晚期糖基化终产物(AGEs)与β淀粉样肽(Aβ)等方面对2型糖尿病脑病的引发进行综述,为其治疗药物的开发提供参考.

The number of patients with type 2 diabetes mellitus (T2DM) shows a rapid increasing trend, and the cognitive dysfunction which is caused by T2DM has been a hot spot of attention, but its pathogenesis are still not entirely clear. In recent years, “the inflammation hypothesis of T2DM” has been mentioned by many researchers, and more and more researches had found that neuroinflammation could act as a trigger for type 2 diabetic encephalopathy (T2DE) which could be mediated by some factors. This review summarizes the factors which could mediate neuroinflammation causing T2DE, including the activation of microglial cells, periphery cytokines, advanced glycation end products (AGEs), β amyloid peptide, and so on, in order to provide reference for the development of treatment drugs.

国家自然科学基金资助项目(81403213)