目的 分析2011—2014年天津医科大学第二医院抗菌药物的使用情况,为合理使用抗菌药物提供依据.方法 采用回顾性调查方法对天津医科大学第二医院2011—2014年抗菌药物的使用情况进行汇总,对抗菌药物的品种、销售金额、用药频度(DDDs)以及日均费用(DDC)进行分析.结果 2011—2014年抗菌药物销售金额比例逐年下降,抗菌药物品种数也呈下降趋势;注射剂型和口服剂型中头孢菌素类药物连续4年销售量和DDDs均是第一位,注射剂型的增幅大于口服剂型;注射用头孢地嗪钠的DDDs排名连续4年均为第一位,且2014年增长幅度最大.同种药品不同年份的DDC值略有差异.结论 2011—2014年天津医科大学第二医院抗菌药物的使用总体规范合理,抗菌药物应用总量及品种数均降低且更加合理,与此同时也发现一些问题,还需进一步加强管理.

Objective To analyze the utilization of antibacterial drugs in the Second Hospital of Tianjin Medical University from 2011 to 2014, and to provide valuable reference for rational use of antibacterial drugs. Methods The utilization of antibacterial drugs in the Second Hospital of Tianjin Medical University from 2011 to 2014 was summarized retrospectively, and the varieties, costs, defined daily doses (DDDs), and defined daily cost (DDC) were analyzed. Results From 2011 to 2014, the proportion of the consumption sum of antibacterial drugs was declining year by year, and several varieties of antibiotics decreased, too. Sales and DDDs of cephalosporins in injection or oral dosage forms both ranked the first for the last four years. The increase of injections was bigger than that of oral dosage forms. DDDs of Cefodizime Sodium for injection ranked the first for the last four years, and the increase in 2014 was the biggest. DDC of the same drug in different years had little difference. Conclusion In general, the utilization of antibacterial drugs in the Second Hospital of Tianjin Medical University from 2011 to 2014 is up to reasonable standard, and the total number of antibacterial drugs and varieties are lower and more reasonable. At the same time, there are also some problems, which need further efforts to strengthen the management.