目的 研究螺旋藻胶囊联合紫杉醇、顺铂治疗晚期宫颈癌的的临床效果.方法 收集2011年3月—2014年1月辽宁省肿瘤医院收治的晚期宫颈癌患者90例,随机分为对照组与治疗组,每组例45例.对照组患者在每个化疗周期的第1天静脉滴注紫杉醇注射液130 mg/m²,静脉滴注注射用顺铂60 mg/m².治疗组口服螺旋藻胶囊,3粒/次,3次/d,其他治疗同对照组.两组21 d为1个化疗疗程,均连续治疗4个疗程.观察两组患者治疗的临床疗效,比较两组Karnofsky(KPS)评分、免疫功能指标的变化,同时观察两组药物的不良反应发生情况.结果 治疗后,对照组和治疗组的总有效率分别为71.11%、88.89%,两组比较差异有统计学意义(P< 0.05).治疗组患者经过治疗后KPS评分、CD³⁺、CD⁴⁺高于治疗前,CD⁸⁺低于治疗前,同组比较差异有统计学意义(P< 0.05).治疗组患者治疗后Karnofsky评分、CD³⁺、CD⁴⁺高于对照组,CD⁸⁺低于对照组,两组比较差异具有统计学意义(P< 0.05).治疗过程中,两组患者均可发生白细胞降低、血小板减少、恶心呕吐、腹泻、贫血、口腔黏膜炎症等毒副反应,但治疗组的发生率低于对照组,两组比较差异有统计学意义(P< 0.05).结论 螺旋藻胶囊联合紫杉醇、顺铂治疗晚期宫颈癌能提高患者的临床疗效,改善患者的生活质量,提高患者的免疫功能,还可减少化疗药物的毒副作用,值得在临床上进一步推广应用.

Objective To explore the clinical effect of Spirulina Capsules combined with paclitaxel and cisplatin in treatment of advanced cervical cancer. Methods The patients with advanced cervical cancer (90 cases) of Liaoning Cancer Hospital & Institute from March 2011 to January 2014 were randomly divided into control and treatment groups, and each group had 45 cases. The patients in the control group were iv administered with Paclitaxel Injection 130 mg/m² and Cisplatin for injection 60 mg/m² on the first day of each chemotherapy cycle. The patients in the treatment group were po administered with Spirulina Capsules, 3 grains/time, three times daily, and other treatment was the same as the control group. One course of treatment was 21 d, and two groups were treated for four courses of chemotherapy. After treatment, the efficacy was evaluated, and the changes of KPS score and immune function indexes were compared. At the same time, drug adverse reactions of two groups were observed. Results After treatment, the total effective rate of control and treatment groups were 71.11% and 88.89%, respectively, and there were differences between two groups (P <0.05). After treatment, KPS score, CD³⁺, CD⁴⁺ in the treatment group were higher than those before the treatment, while CD⁸⁺ was significantly reduced, and the difference was statistically significant in the same group (P <0.05). After treatment CD³⁺, CD⁴⁺ were higher than those in the control group, and CD⁸⁺ was lower than that in the control group, and there were differences between two groups (P <0.05). The incidences of adverse reaction such as white blood cells and platelets reduced, nausea, vomiting, diarrhea, anemia, and inflammation of the oral mucosa were significantly lower than those in the control group. Conclusion Spirulina Capsules combined with paclitaxel and cisplatin can improve the clinical curative effect of advanced cervical cancer, and can improve the quality of life and immune function, while can reduce the adverse reaction of chemotherapy drugs, which is worth clinical popularization and application.