目的 研究新癀片对不同动物模型的解热作用.方法 制备酵母致大鼠发热、牛奶致家兔发热、内毒素致家兔发热模型测量给药后各组的体温,计算各组大鼠体温与基础体温差值以及各给药组降温率.结果 新癀片95.0 mg/kg剂量组在药后1～4.5 h,47.5 mg/kg剂量组药后4、4.5 h对酵母所致大鼠体温升高有显著的抑制作用.药后1 h,新癀片47.5 mg/kg剂量组牛奶致发热家兔体温开始下降;药后2 h,47.5、23.8 mg/kg剂量组家兔体温均下降显著,一直持续到药后5 h,仍有显著的降温作用.新癀片47.5 mg/kg剂量能够显著降低内毒素致发热家兔各时间点体温的升高,在药后4、5 h时对体温的降温率达50.3%、85.2%.结论 新癀片对酵母致大鼠发热、牛奶致家兔发热和内毒素致家兔发热均有很好的解热作用.

Objective To research the antipyretic effects of Xinhuang Tablets on different animal fever models. Methods The rats fever model of yeast-induced, the rabbits fever models of milk-induced and endotoxin-induced were prepared, and body temperatures of animals were measured. The difference of each group between body temperature and basal body temperature and temperature drop rates were calculated. Results Xinhuang Tablets could significantly inhibit rise of body temperature of yeast-caused fever in rats after ig administered during 1-4.5 h at dosage of 95.0 mg/kg, and after ig administered 4 and 4.5 h at dosage of 47.5 mg/kg. The rabbit body temperatures in Xinhuang Tablets 47.5 mg/kg dose group milk-induced fever began to decline after ig administered 1 h, and those in Xinhuang Tablets 47.5, 23.8 mg/kg dose groups both significantly decreased after ig administered 2 h, until 5 h. Xinhuang Tablets could significantly decline the rise of body temperatures in rabbits endotoxin-induced fever at dosage of 47.5 mg/kg each time points, and the temperature drop rates reached 50.3% and 85.2% after ig administered 4 and 5 h. Conclusion Xinhuang Tablets has significant antipyretic effects on rats fever model of yeast-induced, the rabbits fever models of milk-induced and endotoxin-induced.