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[摘要]
目的 探讨分析危重和普通肺部感染新生儿的病原菌和药敏的结果,为进一步临床治疗提供依据。方法 选取菏泽市牡丹区中心医院新生儿科2011年4月—2014年4月收治的126例肺部感染患儿,依据患儿病情状况分为危重组与普通组,每组各63例。入院后对患儿的下呼吸道痰液进行细菌培养和药敏试验。比较两组患儿的病原菌以及药敏结果。结果 危重组及普通组致病菌均以革兰阴性菌为主,但危重组革兰阴性杆菌比例显著高于普通组;革兰阳性菌中,构成比位列首位的为金黄色葡萄球菌。药敏结果显示危重组的大肠埃希菌、铜绿假单胞菌、鲍曼不动杆菌绝大多数为多重耐药菌;来源不同的同一细菌对同一抗生素的敏感率各不相同,危重组的较普通组敏感率普遍降低。结论 新生儿肺部感染病原菌主要为革兰阴性菌,耐药性较高,且呈多重耐药的菌株日趋增加,应引起重视,临床治疗中合理选用抗感染药物极为重要。
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[Abstract]
Objective To investigate the pathogenic bacteria and drug sensitivity analysis of critical and normal neonates with pulmonary infection, and provides basis for further clinical treatment. Methods Neonates (126 cases) with pulmonary infection in department of neonatology in Central Hospital of Mudan District Heze City from April 2011 to April 2014 were divided into critical and common groups based on the disease status. Each had 63 cases. After admission, bacterial cultivation and drug-sensitivity test of sputum in lower respiratory tract of neonates were carried. Pathogenic bacteria and drug sensitivity results were compared between two groups. Results Most of pathogenic bacteria in critical and common group were Gram-negative bacilli, but the proportion of Gram-negative bacilli in critical group was significantly higher than that in common group. The top ratio of Gram-positive bacteria was Staphylococcus aureus. The drug sensitivity results showed the vast majority of Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii in critical group were multidrug resistant bacteria. The sensitive rates of the same bacteria from different sources were different. The sensitive rates of critical group were lower than those of common group. Conclusion Most of pathogenic bacteria of neonates with pulmonary infection are Gram-negative bacilli with higher resistance, and multidrug resistant strains is increasing. It should be paid more attention to the rational use of anti-infective drugs in clinical treatment.
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