目的 调查分析2011—2014年东营市人民医院门诊麻醉药品的应用情况及趋势,为麻醉药品的科学管理和合理应用提供参考。方法 采用回顾性方法,对4 526张门诊麻醉处方的用药数量、用于癌痛的构成比、限定日剂量(DDD)值、用药频度(DDDs)及药物利用指数(DUI)等数据进行统计与分析。结果 处方中共应用9种麻醉类镇痛药物,2011—2014年中药品用量均为前两位的分别是硫酸吗啡控释片和盐酸羟考酮缓释片(20 mg/片);盐酸哌替啶注射液用量呈逐年下降趋势,到2012年已经不用于癌痛治疗;DDDs排前两位的分别是盐酸羟考酮缓释片(20 mg/片)和硫酸吗啡控释片,盐酸布桂嗪注射液的DDDs一直最低。盐酸哌替啶注射液和芬太尼透皮贴的DUI值均≤1,硫酸吗啡控释片的DUI值均 > 1,其他的DUI约为1,且变化不明显。结论 东营市人民医院门诊麻醉药品的管理较规范,癌痛治疗药物结构日趋规范。

Objective To investigate and analyze the application situation and trend of narcotic drugs in outpatient department of People's Hospital of Dongying City during 2011 — 2014, in order to provide reference for scientific management and reasonable application of narcotic drugs. Methods The usage of narcotic drugs in outpatient department to patients (4 526 cases) was summarized retrospectively, and drug dosage, constituent ratio of narcotic drugs for cancer pain relief, defined daily dose (DDD), frequency of drug use (DDDs), and drug utilization index (DUI) were analyzed statistically. Results Nine kinds of narcotic drugs were used. The top two narcotic drugs in drug dosage were Morphine Sulfate Controlled-release Tablets (MST) and Oxycodone Hydrochloride Prolonged-release Tablets (20 mg/tablet). The amount of Pethidine Hydrochloride Injection decreased every year, and was not used for treatment of cancer pain in 2012. The top two narcotic drugs in DDDs were Oxycodone Hydrochloride Prolonged-release Tablets (20 mg/tablet) and MST. DDDs of Bucinnazine Hydrochloride Injection and Fentanyl Transdermal Patch was the lowest. The DUI index of Pethidine Hydrochloride Injection and Fentanyl Transdermal Patch were both less than 1, and the DUI index of MST was more than 1. Others were equal to 1, and the changes were not obvious. Conclusion The use of narcotic drugs in outpatient department of People's Hospital of Dongying City is rational basically, and the structure of drugs used for cancer pain relief is becoming more balanced.